Table 1 Patient characteristics of the ST cohort at inclusion (N = 1174)*
Characteristic | Breast | Lung | GI: colorectal | GI: non-colorectal | GYN: ovarian | GYN: non-ovarian | Head & neck | Prostate | Other§ | Total |
|---|---|---|---|---|---|---|---|---|---|---|
n (% of total) | 356 (30.3) | 280 (23.9) | 103 (8.8) | 69 (5.9) | 72 (6.3) | 39 (3.3) | 104 (8.9) | 66 (5.6) | 81 (6.9) | 1174 |
Age, mean ± SD (years) | 57.7 ± 11.9 | 63.9 ± 10.4 | 66.4 ± 11.4 | 63.9 ± 10.0 | 65.7 ± 11.6 | 66.2 ± 10.9 | 59.7 ± 11.0 | 71.7 ± 7.2 | 61.0 ± 15.6 | 62.3 ± 12 |
≥ 70 years, n (%) | 57 (16.0) | 76 (27.1) | 37 (35.9) | 22 (30.6) | 30 (41.7) | 18 (46.2) | 16 (15.2) | 37 (56.1) | 29 (35.8) | 322 (27.4) |
Female, n (%) | 351 (98.6) | 87 (31.1) | 45 (43.7) | 26 (36.1) | 72 (100) | 39 (100) | 15 (14.3) | 0 (0) | 12 (14.8) | 647 (55.1) |
ECOG PS, n (%) | n = 354 | n = 277 | n = 100 | n = 71 | n = 68 | n = 36 | n = 104 | n = 64 | n = 79 | n = 1153 |
Grade 0–1 | 320 (90.4) | 203 (73.3) | 92 (92.0) | 50 (70.4) | 52 (76.5) | 32 (88.9) | 90 (86.5) | 42 (65.6) | 59 (74.7) | 940 (81.5) |
Grade ≥ 2 | 34 (9.6) | 74 (26.7) | 8 (8.0) | 21 (29.6) | 16 (23.5) | 4 (11.1) | 14 (13.5) | 22 (34.4) | 20 (25.3) | 213 (18.5) |
Comorbidities and pathologies at risk of FN†, n (%) | 40 (11.2) | 121 (43.2) | 22 (21.4) | 20 (27.8) | 14 (19.4) | 7 (17.9) | 23 (21.9) | 24 (36.4) | 32 (39.5) | 303 (25.8) |
Stage of tumour at inclusion, n (%) | ||||||||||
I–IIIb | 261 (73.3) | 82 (29.3) | 23 (22.3) | 13 (18.1) | 31 (43.1) | 9 (23.1) | 52 (49.5) | 2 (3.0) | 25 (30.9) | 498 (42.4) |
IV | 95 (26.7) | 198 (70.7) | 80 (77.7) | 59 (81.9) | 41 (56.9) | 30 (76.9) | 53 (50.5) | 64 (97.0) | 56 (69.1) | 676 (57.6) |
Prior G-CSF, n* (%) | 43 (12.1) | 46 (16.4) | 5 (4.9) | 7 (9.7) | 14 (19.4) | 7 (17.9) | 12 (11.4) | 13 (19.7) | 23 (28.4) | 170 (14.5) |
Prior radiotherapy, n* (%) | 81 (22.8) | 77 (27.5) | 19 (18.4) | 10 (13.9) | 9 (12.5) | 18 (46.2) | 44 (41.9) | 35 (53.0) | 14 (17.3) | 307 (26.1) |
Prior CT, n* (%) | 107 (30.1) | 105 (37.5) | 47 (45.6) | 29 (40.3) | 37 (51.4) | 17 (43.6) | 35 (33.3) | 51 (77.3) | 26 (32.1) | 454 (38.7) |
Prior severe neutropenia, n* (%) | 39 (11.0) | 27 (9.6) | 8 (7.8) | 9 (12.5) | 11 (15.3) | 1 (2.6) | 4 (3.8) | 2 (3.0) | 8 (9.9) | 109 (9.3) |
Grade 3 | 14 (35.9) | 18 (66.7) | 4 (50.0) | 3 (33.3) | 6 (54.5) | 1 (100) | 2 (50.0) | 0 (0) | 1 (12.5) | 49 (45.0) |
Grade 4 | 23 (59.0) | 9 (33.3) | 3 (37.5) | 5 (55.6) | 5 (45.5) | 0 (0) | 1 (25.0) | 1 (50.0) | 8 (100) | 55 (50.5) |
Febrile‡ | 11 (28.2) | 10 (37.0) | 3 (37.5) | 5 (55.6) | 2 (18.2) | 0 (0) | 1 (25.0) | 2 (100) | 5 (62.5) | 39 (35.8) |