The impact of introducing tyrosine kinase inhibitors on chronic myeloid leukemia survival: a population-based study

Table 2 Hazard ratios (HR) for incident cases

	HR	[95% CI]
Cox model for incident cases
Period of diagnosis
Post-TKI vs. Pre-TKI	0.36	0.25	0.52
Sex
F vs. M	0.65	0.45	0.93
Age at diagnosis
65–74 yrs vs. < 65 yrs	3.46	2.19	5.47
> 74 yrs vs. < 65 yrs	8.27	5.16	13.26
Residency
Mountainous vs. non-mountainous	1.13	0.67	1.92
Cox model for incident cases stratified by age at diagnosis
Age at diagnosis < 65 years
incident cases vs. non-incident cases	0.17	0.08	0.39
Age at diagnosis 65–74 years
incident cases vs. non-incident cases	0.52	0.27	0.99
Age at diagnosis > 74 years
incident cases vs. non-incident cases	0.41	0.23	0.73

Hazard ratios for incident cases (diagnosed after February 1, 2002) compared to other cases (diagnosed before February 1, 2002), calculated using Cox regression models adjusted by sex, age at diagnosis and residency (mountainous or non-mountainous area). Interaction between each covariate and time of diagnosis (i.e. incident or non-incident cases) was also assessed. A Cox regression model stratified by age at diagnosis and adjusted for sex and residency for incident cases was also performed

ISSN: 1471-2407