Fig. 4

Interrupted time series analysis: The level change in 3-year (a) and 5-year (b) disease-specific (DS) survival for CML after the introduction of TKI (intervention) was calculated using interrupted time series regression models. Points represent disease-specific survival by year of diagnosis, continuous lines represent pre- and post-intervention trends, the dashed line represents the time of intervention, i.e. the drug’s introduction into clinical practice in February 2002