BMC Cancer

Table 2 Univariable association analyses in the training and validation cohorts

From: Nomogram for predicting preoperative lymph node involvement in patients with invasive micropapillary carcinoma of breast: a SEER population-based study

Characteristics	Training Cohort					Validation Cohort
Characteristics	LN Metastasis (+)		LN Metastasis (−)		p	LN Metastasis (+)		LN Metastasis (−)		p
Age at diagnosis	NO.	%	NO.	%	<0.001	NO.	%	NO.	%	0.001
≤ 50	83	31.56	43	16.29		121	27.07	75	17.32
>50	180	68.44	221	83.71		326	72.93	358	82.68
Ethnicity					0.129					0.033
White	207	78.71	211	79.92		334	74.72	341	78.75
Black	36	13.69	24	9.09		69	15.44	42	9.70
Others	20	7.60	29	10.98		44	9.84	50	11.55
Gender					0.997					0.018
Male	2	0.76	2	0.76		16	3.58	5	1.15
Female	261	99.24	262	99.24		431	96.42	428	98.85
Laterality					0.175					0.502
Left	148	56.27	133	50.38		230	51.45	213	49.19
Right	115	43.73	131	49.62		217	48.55	220	50.81
Tumor size(cm)					<0.001					<0.001
<2	98	37.26	185	70.08		142	31.77	319	73.67
2–5	117	44.49	72	27.27		213	47.65	103	23.79
≥ 5	48	18.25	7	2.65		92	20.58	11	2.54
ER status					0.508					0.837
Positive	226	85.93	232	87.88		406	90.83	395	91.22
Negative	37	14.07	32	12.12		41	9.17	38	8.78
PR status					0.057					0.181
Positive	184	69.96	204	77.27		367	82.10	340	78.52
Negative	79	30.04	60	22.73		80	17.90	93	21.48
Histological grade					0.002					0.001
I	16	6.08	32	12.12		23	5.15	30	6.93
II	116	44.11	131	49.62		229	51.23	270	62.36
III	126	47.91	90	34.09		184	41.16	123	28.41
Unknown	5	1.90	11	4.17		11	2.46	10	2.31
Stage					<0.001					<0.001
I	0	–	196	74.24		0	–	328	75.75
II	146	55.51	65	24.62		246	55.03	97	22.40
III	110	41.83	3	1.14		190	42.51	4	0.92
IV	5	1.90	0	–		7	1.57	1	0.23
Unknown	2	0.76	0	–		4	0.89	3	0.69

LN lymph node, ER estrogen receptor, PR progesterone receptor; p value is derived from the univariable association analyses between each of the clinicopathologic variables and LN status

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