Growth factor genes and change in mammographic density after stopping combined hormone therapy in the California Teachers Study

Table 3 Single nucleotide polymorphisms (SNPs) associated with estrogen and progestin combined therapy (EPT)-associated mammographic density change among nulliparous women after multiple testing correction at gene level; results from parous women (n = 219) are presented for comparison^a

SNP (gene)	Major/minor allele	Minor allele frequency	Nulliparous (n = 63)				Parous (n = 219)				P for interaction^c
SNP (gene)	Major/minor allele	Minor allele frequency	N (WW/WV/VV)	Beta (SE)	P	P_adj ^b	N (WW/WV/VV)	Beta (SE)	P	P_adj^b	P for interaction^c
rs2278200^d (INHA)	C/G	0.45	17/23/15	-3.78 (1.03)	0.0006	0.005	51/114/38	-0.49 (0.68)	0.47	>0.99	0.013
rs907142^d(INHA)	G/C	0.32	27/30/4	3.97 (1.31)	0.004	0.028	82/101/20	0.21 (0.68)	0.76	>0.99	0.007
rs2059693^d (INHA)	C/T	0.28	31/27/4	3.71 (1.27)	0.005	0.033	107/94/16	0.10 (0.68)	0.88	>0.99	0.013
rs1039898 (INHA)	T/C	0.10	50/13/0	5.16 (1.91)	0.009	0.048	183/34/1	-0.14 (1.09)	0.90	>0.99	0.022

^aBased on linear regression model adjusting for age and body mass index (BMI) at time of on-EPT mammogram, time interval and BMI change between the two mammograms, and mammographic density of on-EPT mammogram. Additive genetic model was used
^bMultiple testing corrected P-value; P_ACT (P values adjusted for correlated tests) within each gene was calculated using the methods by Conneely and Boehnke [35]
^cP-values for interaction were not corrected for multiple testing
^drs2278200 and rs907142, r²=0.37; rs907142 and rs2059693, r²=0.55

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