Fig. 3
From: Predominance of triple wild-type and IGF2R mutations in mucosal melanomas
Landscape of mutations in MM. a A mutation status matrix was constructed from MM specimens. Frequently mutated genes along with anatomic subtypes (anorectal, head & neck or genital) and mutation subtype (Triple-WT or non-Triple-WT) were annotated for each specimen. b mutation frequency for IGF2R in different cancer types was investigated using TCGA database and our MM cohort. Bar plots showing frequency of IGF2R mutations along with the types of mutations. UCS: uterine carcinosarcoma, UCEC: uterine corpus endometrial carcinoma, ACC: adrenocortical carcinoma, DLBC: lymphoid neoplasm diffuse large B-cell lymphoma, PAAD: pancreatic adenocarcinoma, STAD: stomach adenocarcinoma, COAD: colon adenocarcinoma, SKCM: skin CM, COADREAD: colorectal adenocarcinoma, STES: stomach and esophageal carcinoma, LIHC: liver hepatocellular carcinoma, LUSC: lung squamous cell carcinoma, READ: rectum adenocarcinoma, LUAD: lung adenocarcinoma, SARC: sarcoma, KIRP: kidney renal papillary cell carcinoma, CESC: cervical squamous cell carcinoma and endocervical adenocarcinoma, BLCA: bladder urothelial carcinoma, HNSC: head and neck squamous cell carcinoma, KICH: kidney chromophobe, TGCT: testicular germ cell tumors, BRCA: breast invasive carcinoma, GBM: glioblastoma multiforme, OV: ovarian serous cystadenocarcinoma, THCA: thyroid carcinoma, and LGG: brain lower grade glioma