Skip to main content

Table 2 Quantitative proteomics by the Tandem Mass Tag (TMT) method

From: Exosomal miR-99a-5p is elevated in sera of ovarian cancer patients and promotes cancer cell invasion by increasing fibronectin and vitronectin expression in neighboring peritoneal mesothelial cells

Functional grouping

Protein

Fold change (miR-99a-5p/NC)

Regulation of catalytic activity

Superoxide dismutase

2.32

Serine/threonine-protein phosphatase

2.23

Antigen processing and presentation of peptide antigen via MHC class I

Antigen peptide transporter 1

2.01

GTP-binding protein SAR1b

1.70

Mitochondrion organization

Stomatin-like protein 2

1.87

Single-stranded DNA-binding protein

1.70

Cell-cell adhesion

60S ribosomal protein L29

1.85

60S ribosomal protein L15

1.72

Acyl-protein thioesterase 2

1.62

ER to Golgi vesicle-mediated transport

Dynactin subunit 1

1.72

Protein transport protein Sec23B

1.66

rRNA processing

40S ribosomal protein S27

1.64

Translation

40S ribosomal protein S26

1.60

Translational initiation

Negative regulation of blood coagulation

PAI-1

1.62

Extracellular matrix organization

Vitronectin

1.53

Fibronectin

1.52

Other

Dipeptidyl peptidase 4

2.03

Thioredoxin-like protein 1

1.88

THO complex subunit 4

1.79

Synaptosomal-associated protein 23

1.66

Tetraspanin

1.64

Cofilin-2

1.63

  1. Fold-changes in expression levels of each protein between HPMCs transfected with miR-99a-5p and those transfected with negative control miRNA are listed. Proteins were categorized by gene ontology (GO) based on biological process (BP) using DAVID 6.8 Functional Annotation Bioinformatics Analysis