Skip to main content
Fig. 3 | BMC Cancer

Fig. 3

From: Numerical analysis of intracellular amino acid profiles of breast cancer cells with K-Ras or PI3K mutation in response to kinase inhibitors

Fig. 3

Global patterns of amino acids in response to oncogenic mutation and kinase inhibitors. The original PCA plot was divided into four graphs for each treatment. a NT (the numeric value is the distance between two IFAA profiles), b REGO, c PI3K-i and d MEK-i. For the treatment reference, the loci for the non-treated cells shown in a were depicted in gray in the other three plots. Each symbol (O: WT, : K-Ras, and □: K-Ras/PI3K) colored in blue and red represents the IFAA of cells at 24 and 48 h, respectively. Dashed arrows were drawn to trace the temporal deviation of amino acid profiles in K-Ras and K-Ras/PI3K treated with each inhibitor. The three circles with radii, rR, rP, and rM indicated a pair of cells (i.e. an inhibitor-treated WT and a mutant cell) with the most similar IFAA profile when treated REGO, PI3K-i, and MEK-i, respectively. rM is the distance for the second nearest pair of cells

Back to article page