Fig. 3From: Numerical analysis of intracellular amino acid profiles of breast cancer cells with K-Ras or PI3K mutation in response to kinase inhibitorsGlobal patterns of amino acids in response to oncogenic mutation and kinase inhibitors. The original PCA plot was divided into four graphs for each treatment. a NT (the numeric value is the distance between two IFAA profiles), b REGO, c PI3K-i and d MEK-i. For the treatment reference, the loci for the non-treated cells shown in a were depicted in gray in the other three plots. Each symbol (O: WT, △: K-Ras, and □: K-Ras/PI3K) colored in blue and red represents the IFAA of cells at 24 and 48 h, respectively. Dashed arrows were drawn to trace the temporal deviation of amino acid profiles in K-Ras and K-Ras/PI3K treated with each inhibitor. The three circles with radii, rR, rP, and rM indicated a pair of cells (i.e. an inhibitor-treated WT and a mutant cell) with the most similar IFAA profile when treated REGO, PI3K-i, and MEK-i, respectively. r′M is the distance for the second nearest pair of cellsBack to article page