Fig. 8From: The small organic molecule C19 binds and strengthens the KRAS4b-PDEδ complex and inhibits growth of colorectal cancer cells in vitro and in vivoSchematic representation of the effect of C19 on the activation of KRAS4b and oncogenic KRAS4b signaling. C19 significantly reduces cellular proliferation by inhibition of the Erk and p38 pathway, and induces apoptosis by inhibiting Akt activationBack to article page