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Fig. 5 | BMC Cancer

Fig. 5

From: The small organic molecule C19 binds and strengthens the KRAS4b-PDEδ complex and inhibits growth of colorectal cancer cells in vitro and in vivo

Fig. 5

C19 treatment reduces tumor size in vivo. a Intraperitoneal (i.p.) C19 treatment at 15 mg/kg and 30 mg/kg (n = 6) daily during 12 days reduces the tumor size in a murine colon cancer xenograft model after injection of LoVo cells. The mean percent changes in tumor volume relative to initial tumor volume are shown. Error bars represent SEM. b Tumor volume distribution after 12 days of LoVo engraftment with vehicle or C19 treatment. n = 6 **p < 0.001; ***p < 0.0001 (upper panel). General observation of tumors at the end of the experiment (lower panel) (c) Body weight was measured daily during treatment. C19 at both concentrations tested did not lower body weight compared to vehicle treatment. Data represent means ± SD of at least three independent experiments

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