Skip to main content

Table 1 Overview of the human cancer types treated with retinoids in clinical studies

From: Traffic lights for retinoids in oncology: molecular markers of retinoid resistance and sensitivity and their use in the management of cancer differentiation therapy

Type of cancer Retinoid Type of treatment Reference
Acute myeloid leukemia ATRA Trial Phase III [101]
Acute promyelocytic leukemia ATRA Trial Phase IV [8]
B-cell lymphoma Fenretinide Trial Phase II [102]
Breast carcinoma ATRA Observational study [103]
Cervical carcinoma 13-cis-RA Trial Phase II [104]
Cutaneous T-cell lymphoma Bexarotene Trial Phase II-III [105]
Ewing’s sarcoma Fenretinide Trial Phase I [106]
13-cis-RA Observational study [107]
Glioblastoma multiforme 13-cis-RA Trial Phase II [108]
Gliomas 13-cis-RA Trial Phase III [109]
Fenretinide Trial Phase II [110]
Hepatocellular carcinoma Polyprenoic acid Observational study [111]
Mantle cell lymphoma Fenretinide Trial Phase II [102]
Medulloblastoma Fenretinide Trial Phase I [106]
13-cis-RA Observational study [107]
Multiple myeloma ATRA Trial Phase II [112]
Neuroblastoma 13-cis-RA Observational study [107]
Trial Phase I [9]
Fenretinide Trial Phase I [106]
Non-small lung cancer ATRA Trial Phase II [113]
Osteosarcoma 13-cis-RA Observational study [107]
Fenretinide Trial Phase I [106]
Ovarian carcinoma Fenretinide Trial Phase II [114]
Pancreatic carcinoma ATRA Trial Phase I [115]
Papillary thyroid cancer 13-cis-RA Observational study [116]
Prostate carcinoma Fenretinide Trial Phase II [117]
Renal carcinoma Fenretinide Trial Phase II [118]
Small cell lung cancer Fenretinide Trial Phase II [119]
Squamous cell carcinoma 13-cis-RA Case series trial [120]
T-cell malignancies 13-cis-RA Phase II [121]
Wilm’s tumor Fenretinide Phase I [106]