From: Increased risk of non-AIDS-defining cancers in Asian HIV-infected patients: a long-term cohort study
Factors | Crude HR (95% CI) | P value | Adjusted HRa (95% CI) | Coefficienta (95% CI) | P value |
---|---|---|---|---|---|
Age < 40 (years) | 1 (reference) |  | 1 (reference) |  |  |
40–49 | 5.1 (2.2–11.6) | < 0.001 | 5.4 (2.4–12.3) | 1.7 (0.9–2.5) | < 0.001 |
50–59 | 12.7 (5.8–27.7) | < 0.001 | 15.3 (6.7–34.6) | 2.7 (1.9–3.5) | < 0.001 |
60–69 | 13.0 (5.0–34.1) | < 0.001 | 17.1 (6.4–46.2) | 2.8 (1.9–3.8) | < 0.001 |
≥ 70 | 36.4 (12.8–103.7) | < 0.001 | 47.3 (16.2–138.1) | 3.9 (2.8–4.9) | < 0.001 |
Sex (male) | 1.3 (0.4–4.2) | 0.653 |  |  |  |
Alcohol drinker | 1.0 (0.6–1.7) | 0.876 |  |  |  |
Smoker | 4.5 (2.5–8.1) | < 0.001 | 5.4 (3.0–9.8) | 1.7 (1.1–2.3) | < 0.001 |
HIV risk group, MSM or unknown | 1 (reference) | Â | 1 (reference) | 1 (reference) | Â |
Heterosexuals | 1.9 (1.0–3.7) | 0.045 | 1.6 (0.8–3.2) | 0.5 (−0.2–1.2) | 0.142 |
Blood transmission | 1.1 (0.5–2.4) | 0.765 | 2.6 (1.2–5.8) | 1.0 (0.1–1.8) | 0.021 |
Injection drug use | 9.1 (2.2–37.7) | 0.002 | 5.4 (1.2–23.3) | 1.7 (0.2–3.2) | 0.025 |
CD4 < 200 (cells/μL) | 0.7 (0.4–1.2) | 0.222 |  |  |  |
HIV VL > 75,000 (log10 copies/mL) | 1.00 (0.6–1.6) | 0.972 |  |  |  |
HBV infection | 1.8 (1.0–3.3) | 0.059 | 1.8 (1.0–3.5) | 0.6 (−0.03–1.2) | 0.060 |
HCV infection | 1.6 (0.9–2.9) | 0.120 |  |  |  |
Hypertension | 1.2 (0.6–2.5) | 0.619 |  |  |  |
Dyslipidemia | 0.8 (0.3–1.7) | 0.494 |  |  |  |
Diabetes mellitus (uncomplicated) | 1.5 (0.7–3.2) | 0.337 |  |  |  |
Diabetes mellitus (end-organ damage) | 2.3 (0.8–6.3) | 0.111 |  |  |  |
Myocardial infarction | 1.8 (0.2–12.8) | 0.569 |  |  |  |
Congestive heart failure | 2.6 (0.6–10.7) | 0.182 |  |  |  |
Peripheral vascular disease | NA* | NA* | Â | Â | Â |
Cerebrovascular disease | 1.9 (0.5–7.8) | 0.373 |  |  |  |
Dementia | 1.2 (0.2–8.7) | 0.857 |  |  |  |
COPD | NA* | NA* | Â | Â | Â |
Connective tissue disease | NA* | NA* | Â | Â | Â |
Peptic ulcer disease | 1.1 (0.3–4.4) | 0.921 |  |  |  |
Chronic kidney disease | 0.5 (0.2–2.1) | 0.352 |  |  |  |
Hemiplegia | NA | NA* | Â | Â | Â |
Chronic liver disease (mild) | 1.2 (0.6–2.5) | 0.680 |  |  |  |
Chronic liver disease (moderate to severe) | 2.6 (1.1–6.6) | 0.037 |  |  |  |