Table 1 Characteristics of patients with metastatic lung cancer and with management of chemotherapy in the public sector and access to FICHCOMP drugs: univariate and multivariate logistic regression analysis (multi-level analysis)
All patients (N = 11,486) | Patients with FICHCOMP drug use (N = 6959) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
n | (% col)a | n | (% row)b | OR [95% CI] | OR [95% CI] | |
Age at inclusion (years) | ||||||
≤ 55 yrs | 2923 | (25.4%) | 2058 | (70.4%) | 1.00 | 1.00 |
56–65 yrs | 4206 | (36.6%) | 2659 | (63.2%) | 0.72 [0.65–0.80] | 0.76 [0.69–0.84] |
≥ 66 yrs | 4357 | (37.9%) | 2242 | (51.5%) | 0.44 [0.40–0.49] | 0.49 [0.44–0.55] |
Gender | ||||||
Men | 8172 | (71.1%) | 4819 | (59.0%) | 0.79 [0.72–0.86] | 0.86 [0.79–0.94] |
Women | 3314 | (28.9%) | 2140 | (64.6%) | 1.00 | 1.00 |
Comorbidities | ||||||
Hypertension | 2584 | (22.5%) | 1370 | (53.0%) | 0.68 [0.62–0.74] | 0.88 [0.80–0.97] |
Diabetes | 1151 | (10.0%) | 567 | (49.3%) | 0.61 [0.54–0.69] | 0.79 [0.69–0.90] |
Renal insufficiency | 224 | (2.0%) | 87 | (38.8%) | 0.41 [0.31–0.54] | 0.55 [0.41–0.73] |
COPD | 1506 | (13.1%) | 744 | (49.4%) | 0.60 [0.54–0.67] | 0.71 [0.63–0.80] |
Pulmonary insufficiency | 461 | (4.0%) | 225 | (48.8%) | 0.60 [0.50–0.73] | 0.73 [0.60–0.88] |
Other chronic lung diseases | 855 | (7.4%) | 444 | (51.9%) | 0.68 [0.59–0.78] | 0.93 [0.79–1.08] |
Type of hospital for first stay with chemotherapyc | ||||||
CH | 5615 | (48.9%) | 3405 | (60.6%) | 1.00 | – |
CHU | 3284 | (28.6%) | 2019 | (61.5%) | 1.03 [0.95–1.13] | – |
CLCC | 1193 | (10.4%) | 716 | (60.0%) | 0.93 [0.81–1.06] | – |
Others | 1394 | (12.1%) | 819 | (58.8%) | 0.91 [0.80–1.03] | – |
Population density of municipality (quartile; population nb hab/km2)c | ||||||
Very low density (≤ 86) | 2891 | (25.2%) | 1693 | (58.6%) | 0.94 [0.83–1.06] | – |
Low density (]86–309]) | 2905 | (25.3%) | 1743 | (60.0%) | 1.02 [0.91–1.15] | – |
High density (]309–2073]) | 2872 | (25.0%) | 1772 | (61.7%) | 1.07 [0.95–1.21] | – |
Very high density (> 2073) | 2818 | (24.5%) | 1751 | (62.1%) | 1.00 | – |
Social deprivation of municipality (quartile) | ||||||
Most deprived | 3031 | (26.4%) | 1762 | (58.1%) | 0.82 [0.73–0.93] | 0.82 [0.72–0.92] |
Deprived | 3249 | (28.3%) | 1958 | (60.3%) | 0.90 [0.80–1.01] | 0.87 [0.78–0.98] |
Privileged | 2461 | (21.4%) | 1493 | (60.7%) | 0.93 [0.82–1.04] | 0.90 [0.80–1.02] |
Most privileged | 2745 | (23.9%) | 1746 | (63.6%) | 1.00 | 1.00 |