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Table 2 Univariate and multivariate analyses of factors associated with biochemical recurrence

From: Clinical significance and predictors of oncologic outcome after radical prostatectomy for invisible prostate cancer on multiparametric MRI

Variable

Univariate

Multivariate

HR (95% CI)

p value

HR (95% CI)

p value

Age, year

1.012 (0.960–1.067)

0.656

  

PSA, ng/ml

1.198 (1.129–1.272)

< 0.001

1.164 (1.069–1.268)

< 0.001

BMI, kg/m2

0.943 (0.813–1.093)

0.433

  

Prostate volume, ml

1.001 (0.981–1.023)

0.892

  

Hypertension

 No

1 (Ref)

   

 Yes

1.548 (0.747–3.210)

0.240

  

DM

 No

1 (Ref)

   

 Yes

0.849 (0.257–2.808)

0.789

  

Biopsy Gleason score

 6

1 (Ref)

 

1 (Ref)

 

 7

1.952 (0.783–4.866)

0.151

0.957 (0.315–2.913)

0.939

  ≥ 8

7.052 (2.956–16.828)

< 0.001

0.985 (0.179–5.434)

0.986

Pathologic Gleason score

 6

1 (Ref)

 

1 (Ref)

 

 7

2.619 (0.982–6.989)

0.054

1.905 (0.653–5.560)

0.238

  ≥ 8

13.213 (4.879–35.778)

< 0.001

5.009 (1.664–15.076)

0.004

Tumor volume at specimen, cc

1.745 (1.263–2.411)

0.001

0.780 (0.499–1.218)

0.275

Pathologic T stage

  ≤ T2

1 (Ref)

 

1 (Ref)

 

  ≥ T3

9.721 (4.630–20.411)

< 0.001

3.621 (1.535–8.540)

0.003

PSM(R1)

 No

1 (Ref)

 

1 (Ref)

 

 Yes

3.935 (1.778–8.706)

0.001

0.800 (0.271–2.363)

0.686

LVI

 No

1 (Ref)

 

1 (Ref)

 

 Yes

8.455 (1.978–36.133)

0.004

5.129 (1.087–24.187)

0.039

PNI

 No

1 (Ref)

   

 Yes

1.677 (0.800–3.514)

0.171

  
  1. HR Hazard ratio, PSA Prostate-specific antigen, BMI Body mass index, DM Diabetes mellitus, PSM Positive surgical margins, LVI Lymphovascular invasion, PNI Perineural invasion
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BMC Cancer

ISSN: 1471-2407

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