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Table 2 Univariate and multivariate analyses of factors associated with biochemical recurrence

From: Clinical significance and predictors of oncologic outcome after radical prostatectomy for invisible prostate cancer on multiparametric MRI

Variable Univariate Multivariate
HR (95% CI) p value HR (95% CI) p value
Age, year 1.012 (0.960–1.067) 0.656   
PSA, ng/ml 1.198 (1.129–1.272) < 0.001 1.164 (1.069–1.268) < 0.001
BMI, kg/m2 0.943 (0.813–1.093) 0.433   
Prostate volume, ml 1.001 (0.981–1.023) 0.892   
Hypertension
 No 1 (Ref)    
 Yes 1.548 (0.747–3.210) 0.240   
DM
 No 1 (Ref)    
 Yes 0.849 (0.257–2.808) 0.789   
Biopsy Gleason score
 6 1 (Ref)   1 (Ref)  
 7 1.952 (0.783–4.866) 0.151 0.957 (0.315–2.913) 0.939
  ≥ 8 7.052 (2.956–16.828) < 0.001 0.985 (0.179–5.434) 0.986
Pathologic Gleason score
 6 1 (Ref)   1 (Ref)  
 7 2.619 (0.982–6.989) 0.054 1.905 (0.653–5.560) 0.238
  ≥ 8 13.213 (4.879–35.778) < 0.001 5.009 (1.664–15.076) 0.004
Tumor volume at specimen, cc 1.745 (1.263–2.411) 0.001 0.780 (0.499–1.218) 0.275
Pathologic T stage
  ≤ T2 1 (Ref)   1 (Ref)  
  ≥ T3 9.721 (4.630–20.411) < 0.001 3.621 (1.535–8.540) 0.003
PSM(R1)
 No 1 (Ref)   1 (Ref)  
 Yes 3.935 (1.778–8.706) 0.001 0.800 (0.271–2.363) 0.686
LVI
 No 1 (Ref)   1 (Ref)  
 Yes 8.455 (1.978–36.133) 0.004 5.129 (1.087–24.187) 0.039
PNI
 No 1 (Ref)    
 Yes 1.677 (0.800–3.514) 0.171   
  1. HR Hazard ratio, PSA Prostate-specific antigen, BMI Body mass index, DM Diabetes mellitus, PSM Positive surgical margins, LVI Lymphovascular invasion, PNI Perineural invasion