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Fig. 10 | BMC Cancer

Fig. 10

From: A novel feedback loop between high MALAT-1 and low miR-200c-3p promotes cell migration and invasion in pancreatic ductal adenocarcinoma and is predictive of poor prognosis

Fig. 10

Schematic model of a novel feedback loop between high MALAT-1 and low miR-200c-3p promotes cell migration and invasion in PDAC. MALAT-1 functioned as a miRNA sponge to attenuate the endogenous function of miR-200c-3p, which negatively modulates ZEB1 expression in PDAC. On the other hand, miR-200c-3p inhibited the level of MALAT-1 expression is somewhat similar to the miRNA-mediated silencing of protein-coding genes

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