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Fig. 1 | BMC Cancer

Fig. 1

From: A novel feedback loop between high MALAT-1 and low miR-200c-3p promotes cell migration and invasion in pancreatic ductal adenocarcinoma and is predictive of poor prognosis

Fig. 1

Elevated level of MALAT-1 inhibits miR-200c-3p expression in PDAC. a High level of MALAT-1 and low level of miR-200c-3p were expressed in PDAC cell lines compared to HPDE. b RT-qPCR was employ to detect the efficiency of MALAT-1 knockdown in AsPC-1 cell line. c, d Twenty miRNAs candidate were chosen to validate in response to knockdown of MALAT-1 in AsPC-1 (c) and CFPAC-1 (d) cell lines. Initial profiling identified three miRNAs, including miR-200c-3p, miR-92b-3p, and miR-181c-5p, that exhibited > 2-fold-change compared with the control, and miR-200c-3p showed the greatest fold-change in response to the MALAT-1 knockdown

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BMC Cancer

ISSN: 1471-2407

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