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Fig. 2 | BMC Cancer

Fig. 2

From: Recombinant PAPP-A resistant insulin-like growth factor binding protein 4 (dBP4) inhibits angiogenesis and metastasis in a murine model of breast cancer

Fig. 2

dBP4 inhibits migration and invasion of 4T1.2luc cells. a Chemotaxis and b invasion of 4T1.2luc cells towards human IGF1 (100 ng/ml), dBP4 (2.5 μg/ml) or IGF1 (100 ng/ml) with dBP4 (2.5 μg/ml). PBS and 5% (v/v) FBS were used as negative and positive controls, respectively. Data (n = 3 independent experiments) are expressed as mean ± SEM of migrated (a) or invaded (b) cells from three fields of view (original magnification 200×) (*P < 0.001, one-way ANOVA with Tukey post hoc test)

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