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Table 2 IC50 values of SCH772984 and MEK162 in parental and resistant cells

From: Generation and characterization of MEK and ERK inhibitors- resistant non-small-cells-lung-cancer (NSCLC) cells

CELL LINE /DRUG

H727

H727-MEK

RI

H727-SCH

RI

SORAFENIB (μM)

4.07 ± 0.39

4.93 ± 0.69

1.2

3.97 ± 0.60

0.9

BYL 719 (μM)

16.98 ± 1.52

25.57 ± 1.72

1.5

24.36 ± 1.21

1.4

ARQ 751 (μM)

9.74 ± 0.62

11.50 ± 0.79

1.2

12.61 ± 0.48

1.3

TORIN-1 (nM)

73.13 ± 13.02

161.3 ± 29.49

2.2

203.7 ± 43.23

2.7

CISPLATIN (μM)

6.45 ± 0.25

7.01 ± 0.72

1.1

5.40 ± 0.49

0.8

OLAPARIB (μM)

126.1 ± 16.75

296.8 ± 65.53

2.3

131.8 ± 7.83

1.0

DOCETAXEL (μM)

9.72 ± 1.24

18.17 ± 2.99

1.8

12.02 ± 1.05

1.2

DOXORUBICIN (μM)

0.94 ± 0.48

2.1 ± 0.55

2.2

15.73 ± 8.72

16.7

  1. Values are mean +/− SD; RI Resistance Index (Ratio of IC50 in resistant cells and in parental cells)