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Table 2 IC50 values of SCH772984 and MEK162 in parental and resistant cells

From: Generation and characterization of MEK and ERK inhibitors- resistant non-small-cells-lung-cancer (NSCLC) cells

CELL LINE /DRUG H727 H727-MEK RI H727-SCH RI
SORAFENIB (μM) 4.07 ± 0.39 4.93 ± 0.69 1.2 3.97 ± 0.60 0.9
BYL 719 (μM) 16.98 ± 1.52 25.57 ± 1.72 1.5 24.36 ± 1.21 1.4
ARQ 751 (μM) 9.74 ± 0.62 11.50 ± 0.79 1.2 12.61 ± 0.48 1.3
TORIN-1 (nM) 73.13 ± 13.02 161.3 ± 29.49 2.2 203.7 ± 43.23 2.7
CISPLATIN (μM) 6.45 ± 0.25 7.01 ± 0.72 1.1 5.40 ± 0.49 0.8
OLAPARIB (μM) 126.1 ± 16.75 296.8 ± 65.53 2.3 131.8 ± 7.83 1.0
DOCETAXEL (μM) 9.72 ± 1.24 18.17 ± 2.99 1.8 12.02 ± 1.05 1.2
DOXORUBICIN (μM) 0.94 ± 0.48 2.1 ± 0.55 2.2 15.73 ± 8.72 16.7
  1. Values are mean +/− SD; RI Resistance Index (Ratio of IC50 in resistant cells and in parental cells)