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Table 1 IC50 values of SCH772984 and MEK162 in parental and resistant cells

From: Generation and characterization of MEK and ERK inhibitors- resistant non-small-cells-lung-cancer (NSCLC) cells

  IC50 MEK162 (nM) RI IC50 SCH772984 (nM) RI
H727 115 135
H727-MEK > 1000 >  9 > 1000 >  9
H727-SCH > 1000 >  9 > 1000 >  9