Fig. 4

Representative western blot analysis showing the ability of SCH772984 to modify the phosphorylation of ERK and other proteins as indicated in the figure in parental H727 cells and in the two MEK and ERK resistant sublines 6 and 24 h after treatment. Cells were treated with a concentration corresponding to the IC50 of the drug in the parental cells and with a concentration 5 times higher (5xIC50)