| Total n | Initiates statin n (%) | Crude OR (95% CI) | p-value | Adjusteda OR (95% CI) | p-value |
---|---|---|---|---|---|---|
Cancer status (binary) | ||||||
 Non-cancer | 113,035 | 26,606 (23.54) | 1 | 0.443 | 1 |  |
 Cancer survivor | 4202 | 968 (23.04) | 0.97 (0.90–1.05) | 0.98 (0.92–1.05) | 0.626 | |
Sex | ||||||
 Males | 82,923 | 18,902 (22.79) | 1 | < 0.001 | 1 | < 0.001 |
 Females | 34,314 | 8672 (25.27) | 1.15 (1.11–1.18) | 1.19 (1.15–1.23) | ||
Age (years) | ||||||
 40–49 | 5437 | 1301 (23.93) | 1 | < 0.001 | 1 | < 0.001 |
 50–59 | 27,489 | 6402 (23.29) | 0.97 (0.90–1.04) | 0.96 (0.89–1.03) | ||
 60–69 | 52,662 | 12,760 (24.23) | 1.02 (0.92–1.12) | 1.00 (0.90–1.10) | ||
 70–79 | 28,478 | 6624 (23.26) | 0.96 (0.87–1.06) | 0.92 (0.83–1.01) | ||
 80+ | 3171 | 487 (15.36) | 0.58 (0.47–0.71) | 0.53 (0.43–0.65) | ||
BMI (kg/m2) | ||||||
  < 18.5 | 948 | 136 (14.35) | 0.62 (0.53–0.73) | < 0.001 |  |  |
 18.5–25 | 28,421 | 6050 (21.29) | 1 |  |  | |
  ≥ 25 | 84,659 | 20,779 (24.54) | 1.2 (1.17–1.24) |  |  | |
 Missing n (%) | 3213 (2.74) |  |  |  |  |  |
Cholesterol (mmol/L) | ||||||
 Normal (< 5) | 22,469 | 2910 (12.95) | 1 | < 0.001 |  |  |
 Moderate - High (5–8) | 88,274 | 22,838 (25.87) | 2.36 (2.25–2.49) |  |  | |
 High (> 8) | 3435 | 1750 (50.95) | 7.1 (6.48–7.78) |  |  | |
 Missing n (%) | 3059 (2.61) |  |  |  |  |  |
Smoking status | ||||||
 Never smoker | 30,500 | 6863 (22.5) | 1 | < 0.001 |  |  |
 Ex-smoker | 48,627 | 11,971 (24.62) | 1.12 (1.08–1.17) |  |  | |
 Current smoker | 38,065 | 8738 (22.96) | 1.03 (0.97–1.09) |  |  | |
 Missing n (%) | 45 (0.04) |  |  |  |  |  |
Alcohol status | ||||||
 Non-drinker | 18,881 | 4598 (24.35) | 1 | < 0.001 |  |  |
 Ex-drinker | 4241 | 1064 (25.09) | 1.04 (0.94–1.15) |  |  | |
 Current drinker |  |  |  |  |  | |
  light | 42,625 | 10,455 (24.53) | 1.01 (0.96–1.06) |  |  | |
  moderate | 6128 | 1475 (24.07) | 0.98 (0.91–1.06) |  |  | |
  heavy | 9483 | 2039 (21.50) | 0.85 (0.77–0.94) |  |  | |
  amount unknown | 4310 | 1009 (23.41) | 0.95 (0.85–1.06) |  |  | |
 Missing n (%) | 31,569 (26.93) |  |  |  |  |  |
Medical history | ||||||
 Diabetes | 5495 | 1853 (33.72) | 1.7 (1.57–1.85) | < 0.001 |  |  |
 Chronic kidney disease | 5833 | 1568 (26.88) | 1.21 (1.11–1.31) | < 0.001 |  |  |
 Chronic liver disease | 2050 | 453 (22.10) | 0.92 (0.83–1.02) | 0.120 |  |  |
Index of Multiple Deprivation quintile | ||||||
 1 (least deprived) | 13,483 | 3133 (23.24) | 1 | < 0.001 |  |  |
 2 | 14,204 | 3143 (22.13) | 0.94 (0.75–1.17) |  |  | |
 3 | 14,756 | 3510 (23.79) | 1.03 (0.82–1.29) |  |  | |
 4 | 59,358 | 13,626 (22.96) | 0.98 (0.84–1.16) |  |  | |
 5 (most deprived) | 15,436 | 4162 (26.96) | 1.22 (0.95–1.56) |  |  | |
Calendar year | ||||||
 2005–07 | 23,643 | 6257 (26.46) | 1 | < 0.001 |  |  |
 2008–10 | 50,030 | 11,461 (22.91) | 0.83 (0.80–0.86) |  |  | |
 2011–13 | 43,564 | 9856 (22.62) | 0.81 (0.78–0.84) |  |  |