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Table 2 Associations between cancer survivorship and covariates, and statin initiation among the high cardiovascular risk cohort

From: Statin use in cancer survivors versus the general population: cohort study using primary care data from the UK clinical practice research datalink

  Total n Initiates statin n (%) Crude OR (95% CI) p-value Adjusteda OR (95% CI) p-value
Cancer status (binary)
 Non-cancer 113,035 26,606 (23.54) 1 0.443 1  
 Cancer survivor 4202 968 (23.04) 0.97 (0.90–1.05) 0.98 (0.92–1.05) 0.626
Sex
 Males 82,923 18,902 (22.79) 1 < 0.001 1 < 0.001
 Females 34,314 8672 (25.27) 1.15 (1.11–1.18) 1.19 (1.15–1.23)
Age (years)
 40–49 5437 1301 (23.93) 1 < 0.001 1 < 0.001
 50–59 27,489 6402 (23.29) 0.97 (0.90–1.04) 0.96 (0.89–1.03)
 60–69 52,662 12,760 (24.23) 1.02 (0.92–1.12) 1.00 (0.90–1.10)
 70–79 28,478 6624 (23.26) 0.96 (0.87–1.06) 0.92 (0.83–1.01)
 80+ 3171 487 (15.36) 0.58 (0.47–0.71) 0.53 (0.43–0.65)
BMI (kg/m2)
  < 18.5 948 136 (14.35) 0.62 (0.53–0.73) < 0.001   
 18.5–25 28,421 6050 (21.29) 1   
  ≥ 25 84,659 20,779 (24.54) 1.2 (1.17–1.24)   
 Missing n (%) 3213 (2.74)      
Cholesterol (mmol/L)
 Normal (< 5) 22,469 2910 (12.95) 1 < 0.001   
 Moderate - High (5–8) 88,274 22,838 (25.87) 2.36 (2.25–2.49)   
 High (> 8) 3435 1750 (50.95) 7.1 (6.48–7.78)   
 Missing n (%) 3059 (2.61)      
Smoking status
 Never smoker 30,500 6863 (22.5) 1 < 0.001   
 Ex-smoker 48,627 11,971 (24.62) 1.12 (1.08–1.17)   
 Current smoker 38,065 8738 (22.96) 1.03 (0.97–1.09)   
 Missing n (%) 45 (0.04)      
Alcohol status
 Non-drinker 18,881 4598 (24.35) 1 < 0.001   
 Ex-drinker 4241 1064 (25.09) 1.04 (0.94–1.15)   
 Current drinker      
  light 42,625 10,455 (24.53) 1.01 (0.96–1.06)   
  moderate 6128 1475 (24.07) 0.98 (0.91–1.06)   
  heavy 9483 2039 (21.50) 0.85 (0.77–0.94)   
  amount unknown 4310 1009 (23.41) 0.95 (0.85–1.06)   
 Missing n (%) 31,569 (26.93)      
Medical history
 Diabetes 5495 1853 (33.72) 1.7 (1.57–1.85) < 0.001   
 Chronic kidney disease 5833 1568 (26.88) 1.21 (1.11–1.31) < 0.001   
 Chronic liver disease 2050 453 (22.10) 0.92 (0.83–1.02) 0.120   
Index of Multiple Deprivation quintile
 1 (least deprived) 13,483 3133 (23.24) 1 < 0.001   
 2 14,204 3143 (22.13) 0.94 (0.75–1.17)   
 3 14,756 3510 (23.79) 1.03 (0.82–1.29)   
 4 59,358 13,626 (22.96) 0.98 (0.84–1.16)   
 5 (most deprived) 15,436 4162 (26.96) 1.22 (0.95–1.56)   
Calendar year
 2005–07 23,643 6257 (26.46) 1 < 0.001   
 2008–10 50,030 11,461 (22.91) 0.83 (0.80–0.86)   
 2011–13 43,564 9856 (22.62) 0.81 (0.78–0.84)   
  1. aAdjusted for a priori confounders (age and gender). No other covariates changed the association between cancer survivorship and statin initiation by more than 10%