Skip to main content

Table 2 Associations between cancer survivorship and covariates, and statin initiation among the high cardiovascular risk cohort

From: Statin use in cancer survivors versus the general population: cohort study using primary care data from the UK clinical practice research datalink

 

Total n

Initiates statin n (%)

Crude OR (95% CI)

p-value

Adjusteda OR (95% CI)

p-value

Cancer status (binary)

 Non-cancer

113,035

26,606 (23.54)

1

0.443

1

 

 Cancer survivor

4202

968 (23.04)

0.97 (0.90–1.05)

0.98 (0.92–1.05)

0.626

Sex

 Males

82,923

18,902 (22.79)

1

< 0.001

1

< 0.001

 Females

34,314

8672 (25.27)

1.15 (1.11–1.18)

1.19 (1.15–1.23)

Age (years)

 40–49

5437

1301 (23.93)

1

< 0.001

1

< 0.001

 50–59

27,489

6402 (23.29)

0.97 (0.90–1.04)

0.96 (0.89–1.03)

 60–69

52,662

12,760 (24.23)

1.02 (0.92–1.12)

1.00 (0.90–1.10)

 70–79

28,478

6624 (23.26)

0.96 (0.87–1.06)

0.92 (0.83–1.01)

 80+

3171

487 (15.36)

0.58 (0.47–0.71)

0.53 (0.43–0.65)

BMI (kg/m2)

  < 18.5

948

136 (14.35)

0.62 (0.53–0.73)

< 0.001

  

 18.5–25

28,421

6050 (21.29)

1

  

  ≥ 25

84,659

20,779 (24.54)

1.2 (1.17–1.24)

  

 Missing n (%)

3213 (2.74)

     

Cholesterol (mmol/L)

 Normal (< 5)

22,469

2910 (12.95)

1

< 0.001

  

 Moderate - High (5–8)

88,274

22,838 (25.87)

2.36 (2.25–2.49)

  

 High (> 8)

3435

1750 (50.95)

7.1 (6.48–7.78)

  

 Missing n (%)

3059 (2.61)

     

Smoking status

 Never smoker

30,500

6863 (22.5)

1

< 0.001

  

 Ex-smoker

48,627

11,971 (24.62)

1.12 (1.08–1.17)

  

 Current smoker

38,065

8738 (22.96)

1.03 (0.97–1.09)

  

 Missing n (%)

45 (0.04)

     

Alcohol status

 Non-drinker

18,881

4598 (24.35)

1

< 0.001

  

 Ex-drinker

4241

1064 (25.09)

1.04 (0.94–1.15)

  

 Current drinker

     

  light

42,625

10,455 (24.53)

1.01 (0.96–1.06)

  

  moderate

6128

1475 (24.07)

0.98 (0.91–1.06)

  

  heavy

9483

2039 (21.50)

0.85 (0.77–0.94)

  

  amount unknown

4310

1009 (23.41)

0.95 (0.85–1.06)

  

 Missing n (%)

31,569 (26.93)

     

Medical history

 Diabetes

5495

1853 (33.72)

1.7 (1.57–1.85)

< 0.001

  

 Chronic kidney disease

5833

1568 (26.88)

1.21 (1.11–1.31)

< 0.001

  

 Chronic liver disease

2050

453 (22.10)

0.92 (0.83–1.02)

0.120

  

Index of Multiple Deprivation quintile

 1 (least deprived)

13,483

3133 (23.24)

1

< 0.001

  

 2

14,204

3143 (22.13)

0.94 (0.75–1.17)

  

 3

14,756

3510 (23.79)

1.03 (0.82–1.29)

  

 4

59,358

13,626 (22.96)

0.98 (0.84–1.16)

  

 5 (most deprived)

15,436

4162 (26.96)

1.22 (0.95–1.56)

  

Calendar year

 2005–07

23,643

6257 (26.46)

1

< 0.001

  

 2008–10

50,030

11,461 (22.91)

0.83 (0.80–0.86)

  

 2011–13

43,564

9856 (22.62)

0.81 (0.78–0.84)

  
  1. aAdjusted for a priori confounders (age and gender). No other covariates changed the association between cancer survivorship and statin initiation by more than 10%