| |
Total n
|
Initiates statin n (%)
|
Crude OR (95% CI)
|
p-value
|
Adjusteda OR (95% CI)
|
p-value
|
|---|
|
Cancer status (binary)
|
|
Non-cancer
|
113,035
|
26,606 (23.54)
|
1
|
0.443
|
1
| |
|
Cancer survivor
|
4202
|
968 (23.04)
|
0.97 (0.90–1.05)
|
0.98 (0.92–1.05)
|
0.626
|
|
Sex
|
|
Males
|
82,923
|
18,902 (22.79)
|
1
|
< 0.001
|
1
|
< 0.001
|
|
Females
|
34,314
|
8672 (25.27)
|
1.15 (1.11–1.18)
|
1.19 (1.15–1.23)
|
|
Age (years)
|
|
40–49
|
5437
|
1301 (23.93)
|
1
|
< 0.001
|
1
|
< 0.001
|
|
50–59
|
27,489
|
6402 (23.29)
|
0.97 (0.90–1.04)
|
0.96 (0.89–1.03)
|
|
60–69
|
52,662
|
12,760 (24.23)
|
1.02 (0.92–1.12)
|
1.00 (0.90–1.10)
|
|
70–79
|
28,478
|
6624 (23.26)
|
0.96 (0.87–1.06)
|
0.92 (0.83–1.01)
|
|
80+
|
3171
|
487 (15.36)
|
0.58 (0.47–0.71)
|
0.53 (0.43–0.65)
|
|
BMI (kg/m2)
|
|
< 18.5
|
948
|
136 (14.35)
|
0.62 (0.53–0.73)
|
< 0.001
| | |
|
18.5–25
|
28,421
|
6050 (21.29)
|
1
| | |
|
≥ 25
|
84,659
|
20,779 (24.54)
|
1.2 (1.17–1.24)
| | |
|
Missing n (%)
|
3213 (2.74)
| | | | | |
|
Cholesterol (mmol/L)
|
|
Normal (< 5)
|
22,469
|
2910 (12.95)
|
1
|
< 0.001
| | |
|
Moderate - High (5–8)
|
88,274
|
22,838 (25.87)
|
2.36 (2.25–2.49)
| | |
|
High (> 8)
|
3435
|
1750 (50.95)
|
7.1 (6.48–7.78)
| | |
|
Missing n (%)
|
3059 (2.61)
| | | | | |
|
Smoking status
|
|
Never smoker
|
30,500
|
6863 (22.5)
|
1
|
< 0.001
| | |
|
Ex-smoker
|
48,627
|
11,971 (24.62)
|
1.12 (1.08–1.17)
| | |
|
Current smoker
|
38,065
|
8738 (22.96)
|
1.03 (0.97–1.09)
| | |
|
Missing n (%)
|
45 (0.04)
| | | | | |
|
Alcohol status
|
|
Non-drinker
|
18,881
|
4598 (24.35)
|
1
|
< 0.001
| | |
|
Ex-drinker
|
4241
|
1064 (25.09)
|
1.04 (0.94–1.15)
| | |
|
Current drinker
| | | | | |
|
light
|
42,625
|
10,455 (24.53)
|
1.01 (0.96–1.06)
| | |
|
moderate
|
6128
|
1475 (24.07)
|
0.98 (0.91–1.06)
| | |
|
heavy
|
9483
|
2039 (21.50)
|
0.85 (0.77–0.94)
| | |
|
amount unknown
|
4310
|
1009 (23.41)
|
0.95 (0.85–1.06)
| | |
|
Missing n (%)
|
31,569 (26.93)
| | | | | |
|
Medical history
|
|
Diabetes
|
5495
|
1853 (33.72)
|
1.7 (1.57–1.85)
|
< 0.001
| | |
|
Chronic kidney disease
|
5833
|
1568 (26.88)
|
1.21 (1.11–1.31)
|
< 0.001
| | |
|
Chronic liver disease
|
2050
|
453 (22.10)
|
0.92 (0.83–1.02)
|
0.120
| | |
|
Index of Multiple Deprivation quintile
|
|
1 (least deprived)
|
13,483
|
3133 (23.24)
|
1
|
< 0.001
| | |
|
2
|
14,204
|
3143 (22.13)
|
0.94 (0.75–1.17)
| | |
|
3
|
14,756
|
3510 (23.79)
|
1.03 (0.82–1.29)
| | |
|
4
|
59,358
|
13,626 (22.96)
|
0.98 (0.84–1.16)
| | |
|
5 (most deprived)
|
15,436
|
4162 (26.96)
|
1.22 (0.95–1.56)
| | |
|
Calendar year
|
|
2005–07
|
23,643
|
6257 (26.46)
|
1
|
< 0.001
| | |
|
2008–10
|
50,030
|
11,461 (22.91)
|
0.83 (0.80–0.86)
| | |
|
2011–13
|
43,564
|
9856 (22.62)
|
0.81 (0.78–0.84)
| | |
- aAdjusted for a priori confounders (age and gender). No other covariates changed the association between cancer survivorship and statin initiation by more than 10%
