Table 1 Baseline characteristics for the main study cohort and sub-populations by cancer survivor (> = 1 year) status
| Â | Main Study Cohorta | High Cardiovascular Risk Cohortb | Statin Initiator Cohortc | |||
|---|---|---|---|---|---|---|
Cancer Survivor | Control | Cancer Survivor | Control | Cancer Survivor | Control | |
n = 131,676 | n = 3,324,152 | n = 4202 | n = 113,035 | n = 12,142 | n = 366,280 | |
n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |
Sex | ||||||
 Male | 58,587 (44.7) | 1,618,820 (48.70) | 2659 (63.3) | 80,264 (71.0) | 5959 (49.1) | 194,430 (53.1) |
 Female | 72,823 (55.3) | 1,705,299 (51.30) | 1543 (36.7) | 32,771 (29.0) | 6183 (50.9) | 171,848 (46.9) |
Age (years) | ||||||
 Median (IQR) | 66.5 (57.5–75.5) | 50.5 (42.1–62.3) | 69.1 (64.2–72.9) | 64.2 (58.4–69.8) | 68.9 (62.4–75.1) | 62.6 (54.9–70.2) |
 40–49 | 14,117 (10.7) | 1,529,272 (46.0) | 27 (0.6) | 5410 (4.8) | 351 (2.9) | 45,132 (12.3) |
 50–59 | 24,564 (18.6) | 775,972 (23.3) | 368 (8.8) | 27,121 (24.0) | 1630 (13.4) | 96,664 (26.7) |
 60–69 | 38,078 (28.9) | 521,777 (15.7) | 1815 (43.2) | 50,847 (45.0) | 4393 (36.2) | 125,540 (34.3) |
 70–79 | 33,983 (25.8) | 303,231 (9.1) | 1765 (42.0) | 26,713 (23.6) | 4086 (33.7) | 73,598 (20.1) |
 80+ | 20,934 (15.9) | 193,900 (5.8) | 227 (5.4) | 2944 (2.6) | 1682 (13.7) | 25,346 (6.9) |
BMI (kg/m2) | ||||||
 Mean (SD) | 26.9 (5.3) | 26.9 (5.3) | 28.3 (4.8) | 27.8 (5.1) | 28.2 (5.4) | 28.7 (5.6) |
  < 18.5 | 2748 (2.1) | 48,109 (1.4) | 50 (1.2) | 897 (0.8) | 131 (1.1) | 2906 (0.8) |
 18.5–25 | 46,037 (35.0) | 1,130,838 (34.0) | 1127 (26.8) | 27,294 (24.2) | 3175 (26.9) | 86,962 (24.5) |
  ≥ 25 | 74,375 (56.5) | 1,736,648 (52.2) | 2925 (69.6) | 81,734 (72.3) | 8504 (72.0) | 265,128 (74.7) |
 Missing | 8516 (6.5) | 408,557 (12.3) | 100 (2.4) | 3113 (2.8) | 332 (2.7) | 11,285 (3.1) |
Cholesterol (mmol/L) | ||||||
 Mean (SD) | 5.3 (1.2) | 5.4 (1.1) | 5.7 (1.0) | 5.8 (1.1) | 6.0 (1.3) | 6.1 (1.3) |
 Normal (< 5) | 42,503 (32.3) | 796,230 (23.9) | 898 (21.4) | 21,543 (19.1) | 2242 (18.7) | 58,780 (16.2) |
 Mod (5–8) | 62,529 (47.5) | 1,405,997 (42.3) | 3137 (74.6) | 85,221 (75.4) | 8965 (74.8) | 278,848 (76.9) |
 High (> 8) | 1704 (1.5) | 38,297 (1.2) | 92 (2.2) | 3316 (2.9) | 775 (6.47) | 25,032 (6.9) |
 Missing | 24,940 (18.9) | 1,083,578 (32.6) | 75 (1.8) | 2955 (2.6) | 157 (1.29) | 3640 (1.0) |
Smoking status | ||||||
 Never | 46,606 (35.4) | 1,358,706 (40.9) | 1194 (28.4) | 29,306 (25.9) | 3729 (30.7) | 118,728 (32.4) |
 Ex | 61,969 (47.1) | 965,510 (29.1) | 2133 (50.8) | 46,494 (41.2) | 6572 (54.1) | 166,482 (45.5) |
 Current | 22,627 (17.2) | 885,915 (26.6) | 875 (20.8) | 37,190 (32.9) | 1840 (15.2) | 80,841 (22.1) |
 Missing | 474 (0.4) | 114,021 (3.4) | < 5 | 45 (0.0) | < 5 | 299 (0.1) |
Alcohol status (non- ex- current drinker) | ||||||
 Non | 25,030 (19.0) | 577,211 (17.4) | 742 (17.7) | 18,139 (16.1) | 2500 (27.3) | 75,516 (27.5) |
 Ex | 3778 (2.84) | 74,249 (2.2) | 162 (3.9) | 4079 (3.6) | 447 (4.9) | 13,002 (4.7) |
 Current | ||||||
  light | 48,354 (36.7) | 1,042,681 (31.3) | 1629 (38.8) | 40,996 (36.3) | 4868 (53.1) | 140,039 (51.0) |
  moderate | 4776 (3.6) | 106,934 (3.2) | 224 (5.3) | 5904 (5.2) | 503 (5.5) | 15,837 (5.8) |
  heavy | 5025 (3.8) | 150,372 (4.5) | 254 (6.0) | 9229 (8.2) | 562 (6.1) | 19,668 (7.2) |
  unknown | 2819 (2.1) | 74,769 (2.3) | 117 (2.8) | 4193 (3.7) | 280 (3.1) | 10,747 (3.9) |
 Missing | 41,894 (31.8) | 1,297,936 (39.0) | 1074 (25.6) | 30,495 (27.0) | 2982 (24.6) | 91,474 (25.0) |
Medical history | ||||||
 Diabetes | 12,045 (9.2) | 153,405 (4.6) | 187 (4.5) | 5308 (4.7) | 2239 (18.4) | 69,156 (18.9) |
 CKD | 9577 (7.3) | 28,419 (0.9) | 368 (8.8) | 5465 (4.8) | 1450 (12.0) | 24,464 (6.7) |
 Chronic liver disease | 2223 (1.7) | 39,429 (1.2) | 75 (1.8) | 7975 (1.8) | 221 (1.8) | 6378 (1.7) |
Index of Multiple Deprivation quintile | ||||||
 1 (least) | 16,993 (12.9) | 298,566 (9.0) | 641 (15.2) | 12,842 (11.4) | 1697 (11.1) | 40,458 (11.1) |
  2 | 12,043 (12.9) | 340,205 (10.2) | 588 (14.0) | 13,616 (12.6) | 1607 (13.2) | 43,074 (11.8) |
  3 | 18,708 (14.2) | 384,484 (11.6) | 545 (13.0) | 14,211 (12.6) | 1655 (13.6) | 48,491 (13.2) |
  4 | 64,007 (48.6) | 1,978,653 (59.5) | 1894 (45.1) | 57,464 (50.8) | 5615 (46.2) | 188,142 (51.4) |
 5 (most) | 14,985 (11.4) | 322,244 (9.7) | 434,534 (12.7) | 14,902 (13.2) | 1586 (13.1) | 46,115 (12.6) |
Calendar year | ||||||
 2005–07 | 62,916 (47.8) | 2,423,116 (72.9) | 623 (14.8) | 23,020 (20.4) | 4105 (33.8) | 156,589 (42.8) |
 2008–10 | 34,416 (26.1) | 471,289 (14.2) | 1681 (40.0) | 48,349 (42.8) | 4310 (35.5) | 124,339 (33.9) |
 2011–13 | 34,344 (26.1) | 429,747 (12.9) | 1898 (45.2) | 41,666 (36.9) | 3727 (30.7) | 85,352 (23.3) |