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Table 2 Selected anticancer drugs that alter cytotoxicity when combined with DHA in MDA-MB-231 cells

From: Sorafenib and docosahexaenoic acid act in synergy to suppress cancer cell viability: a role of heme oxygenase 1

Enhanced cytotoxicitya

Attenuated cytotoxicityb

Drug code

Drug name

Drug code

Drug name

92859

Arsenic trioxide

63878

Cytarabine

747971

Sorafenib

756645

Crizotinib

757441

Axitinib

743414

Imatinib

296961

Amifostine

3053

Dactinomycin

8806

Melphalan

180973

Tamoxifemn

698037

Pemetrexed Disodium

266046

Oxaliplatin

747974

Raloxifene HCl

721517

Zoledronic acid

754143

Romidepsin

719276

Fulvestra

  1. ap < 0.01, bp < 0.05
  2. MDA-MB231 cells were treated with individual drugs at concentrations of IC25 and IC50 and DHA at 25, 50, and 100 μM for 48 h. Cell viability was determined by MTS assay. Significant enhancement or attenuation of DHA’s cytotoxicity was determined by two-way ANOVA followed by paired analysis
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BMC Cancer

ISSN: 1471-2407

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