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Table 2 Selected anticancer drugs that alter cytotoxicity when combined with DHA in MDA-MB-231 cells

From: Sorafenib and docosahexaenoic acid act in synergy to suppress cancer cell viability: a role of heme oxygenase 1

Enhanced cytotoxicitya Attenuated cytotoxicityb
Drug code Drug name Drug code Drug name
92859 Arsenic trioxide 63878 Cytarabine
747971 Sorafenib 756645 Crizotinib
757441 Axitinib 743414 Imatinib
296961 Amifostine 3053 Dactinomycin
8806 Melphalan 180973 Tamoxifemn
698037 Pemetrexed Disodium 266046 Oxaliplatin
747974 Raloxifene HCl 721517 Zoledronic acid
754143 Romidepsin 719276 Fulvestra
  1. ap < 0.01, bp < 0.05
  2. MDA-MB231 cells were treated with individual drugs at concentrations of IC25 and IC50 and DHA at 25, 50, and 100 μM for 48 h. Cell viability was determined by MTS assay. Significant enhancement or attenuation of DHA’s cytotoxicity was determined by two-way ANOVA followed by paired analysis