Association between ATM rs1801516 polymorphism and cancer susceptibility: a meta-analysis involving 12,879 cases and 18,054 controls

Gu, Yulu; Shi, Jikang; Qiu, Shuang; Qiao, Yichun; Zhang, Xin; Cheng, Yi; Liu, Yawen

doi:10.1186/s12885-018-4941-1

Table 4 The meta-regression results of the association between the rs1801516 polymorphism and cancer risk

From: Association between ATM rs1801516 polymorphism and cancer susceptibility: a meta-analysis involving 12,879 cases and 18,054 controls

Comparisons	Coef.	Std. Err.	t	P	95% CI	τ ²	I² res (%)	Adj R² (%)	F	P _J
AA+GA vs GG
Region-specified population						0.209	93.570	−7.280	0.580	0.676
European	−1.245	4.907	−0.250	0.801	(−11.280, 8.790)
North American	1.646	5.043	0.330	0.747	(−8.668, 11.959)
South American	0.128	5.853	0.020	0.983	(−11.843, 12.098)
Asian	−1.132	5.520	− 0.210	0.839	(−12.421, 10.157)
Oceanian	referent	referent	referent	referent	referent
Cancer type						0.221	94.150	−13.690	0.360	0.870
Breast cancer	2.273	3.744	0.610	0.549	(−5.396, 9.942)
Cervical cancer	−0.220	4.474	− 0.050	0.961	(−9.383, 8.944)
Lung cancer	0.304	5.996	0.050	0.960	(−11.979, 12.587)
Thyroid cancer	−0.147	3.830	− 0.040	0.970	(−7.993, 7.698)
Other cancer	−0.049	3.927	−0.010	0.990	(−8.093, 7.996)
Colorectal cancer	referent	referent	referent	referent	referent
Source of controls	2.066	1.965	1.050	0.303	(−1.974, 6.106)	0.246	94.590	0.040
Matched controls	−2.282	1.640	−1.390	0.174	(−5.624, 1.059)	0.189	93.410	2.740
Family history	4.0038	1.866	2.150	0.040	(0.204, 7.804)	0.174	93.400	10.750
Sample size	−1.069	1.8193	−0.59	0.561	(−4.774, 2.637)	0.200	93.410	−2.600
HWE in controls	−0.175	0.2304	−0.76	0.454	(−0.645, 0.295)	0.001	71.000	−8.060
GA vs GG
Region-specified population						0.219	93.930	−4.290	0.800	0.538
European	−1.233	5.004	−0.250	0.807	(−11.500, 9.033)
North American	2.528	5.217	0.480	0.632	(−8.176, 13.231)
South American	0.239	5.969	0.040	0.968	(−12.009, 12.487)
Asian	−1.256	5.629	−0.220	0.825	(−12.807, 10.295)
Oceanian	referent	referent	referent	referent	referent
Cancer type						0.241	94.510	−15.000	0.340	0.887
Breast cancer	2.241	3.895	0.580	0.570	(−5.764, 10.247)
Cervical cancer	−0.400	4.654	−0.090	0.932	(−9.967, 9.167)
Lung cancer	0.167	6.238	0.030	0.979	(−12.656, 12.990)
Thyroid cancer	−0.176	4.087	−0.040	0.966	(−8.576, 8.225)
Other cancer	−0.147	4.086	−0.040	0.972	(−8.545, 8.251)
Colorectal cancer	referent	referent	referent	referent	referent
Source of controls	2.226	2.125	1.050	0.305	(−2.160, 6.612)	0.267	94.950	0.030
Matched controls	−2.547	1.753	−1.450	0.157	(−6.127, 1.033)	0.202	93.760	3.530
Family history	4.084	1.944	2.100	0.044	(0.113, 8.055)	0.187	93.750	10.770
Sample size	−1.178	1.903	−0.620	0.541	(−5.065, 2.709)	0.215	93.760	−2.580
HWE in controls	−0.206	0.250	−0.820	0.417	(−0.717, 0.305)	0.001	71.820	−9.320
GG + AA vs GA
Region-specified population						0.001	68.410	−6.390	0.800	0.534
European	0.659	0.717	0.920	0.366	(−0.813, 2.131)
North American	0.595	0.736	0.810	0.426	(−0.915, 2.106)
South American	0.006	0.816	0.010	0.994	(−1.668, 1.680)
Asian	0.618	0.781	0.790	0.435	(−0.984, 2.221)
Oceanian	referent	referent	referent	referent	referent
Cancer type						0.001	69.840	−42.350	0.570	0.719
Breast cancer	0.167	0.407	0.410	0.685	(−0.669, 1.003)
Cervical cancer	0.500	0.500	1.000	0.327	(−0.529, 1.529)
Lung cancer	−0.065	0.615	−0.110	0.917	(−1.329, 1.199)
Thyroid cancer	0.458	0.428	1.070	0.294	(−0.422, 1.338)
Other cancer	0.193	0.418	0.460	0.648	(−0.666, 1.052)
Colorectal cancer	referent	referent	referent	referent	referent
Source of controls	−0.028	0.240	−0.120	0.907	(−0.523, 0.467)	0.002	73.660	−13.140
Matched controls	0.130	0.186	0.700	0.491	(−0.250, 0.509)	0.001	67.720	−21.020
Family history	−0.214	0.221	−0.970	0.340	(−0.666, 0.237)	0.001	67.750	−18.530
Sample size	−0.086	0.184	−0.470	0.643	(−0.463, 0.290)	0.001	67.700	−15.790
HWE in controls	0.055	0.263	0.210	0.836	(−0.484, 0.594)	0.001	68.690	−17.640

P_J: P value of the joint test for all variables
Significant 95% CIs and P values were in bold

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ISSN: 1471-2407

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