Fig. 4

Trial sequential analysis of the association between rs1801516 polymorphism and overall cancer risk. The required information size was calculated based on a two side α = 5%, β = 25% (power 80%), and a relative risk reduction of 20%. a recessive model: AA vs GG + GA; b dominant model: AA+GA vs GG; c codominant model: AA vs GG; d codominant model: GA vs GG; e overdominant model: AA+GG vs GA