Fig. 3
From: Genetic and immunological biomarkers predict metastatic disease recurrence in stage III colon cancer
a Results of the unsupervised two-Step Cluster Analysis. Three groups of patients were identified depending on their molecular signature. The descending order of the molecular markers reflects the assumed significance of the predictor. Right panel: Distant-metastasis-free survival depending on the cluster allocation. Mut, mutation, MSI, high-grade microsatellite instability (Cluster analysis by R algorithm, log rank Mantel Cox). b In the subgroup of patients treated with 5-FU adjuvant monotherapy, distant-metastasis-free survival is associated with the intratumoral expression level of the WNT-marker osteopontin, as well as with intratumoral CD8 T-cell density (log rank)