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Table 5 Surgical outcomes among patients undergoing radical cystectomy by antidepressant use before cancer diagnosis

From: Preadmission antidepressant use and bladder cancer: a population-based cohort study of stage at diagnosis, time to surgery, and surgical outcomes

Surgical outcome Non-users AD users
Length of stay (LOS)
 Days admitted, median (IQR) 10 (7–13) 9 (8–13)
 Unadjusted ratio of median LOS (95% CI) Ref. 1.03 (0.95–1.13)
 Adjusteda ratio of median LOS (95% CI) Ref. 1.02 (0.93–1.12)
30-day acute readmission
 Total, n 2241 151
 Readmitted, n 747 62
 Cumulative incidence, % (95% CI) 33.4 (31.4–35.3) 41.1 (33.2–48.8)
 Unadjusted HR (95% CI) Ref. 1.36 (1.08–1.71)
 Adjusteda HR (95% CI) Ref. 1.33 (1.05–1.67)
90-day postoperative procedure
 Total, n 2370 162
 Procedures, n 908 72
 Cumulative incidence, % (95% CI) 38.3 (36.4–40.3) 44.4 (36.7–51.9)
 Unadjusted HR (95% CI) Ref. 1.19 (0.93–1.51)
 Adjusted* HR (95% CI) Ref. 1.18 (0.93–1.51)
One-year all-cause mortality
 Total, n 2370 162
 Deaths, n 330 24
 Cumulative incidence, % (95% CI) 14.4 (13.1–16.0) 15.0 (10.3–21.6)
 Unadjusted HR (95% CI) Ref. 1.05 (0.69–1.58)
 Adjusteda HR (95% CI) Ref. 0.96 (0.63–1.46)
Three-year all-cause mortality   
 Total, n 2370 162
 Deaths, n 650 52
 Cumulative incidence, % (95% CI) 31.3 (29.3–33.4) 35.4 (28.1–43.8)
 Unadjusted HR (95% CI) Ref. 1.16 (0.88–1.54)
 Adjusteda HR (95% CI) Ref. 1.02 (0.77–1.36)
  1. The analysis of acute readmission excludes patients with a primary admission longer than 30 days (n = 140). AD antidepressant, IQR interquartile range, CI confidence interval, HR hazard ratio. aAdjusted for age, sex, CCI, alcohol-related disorders, and marital status