Fig. 2

The ingenuity pathway analysis of immune-related effects of CTNNB1 and CD274. CD274 to cell death: active CD274 decreases apoptosis of cells. Inhibition of active CD274 increases apoptosis of cells. CD274 to cell proliferation of T lymphocytes: active CD274 decreases proliferation of T cells. CD274 to differentiation od T lymphocytes: mutant CD274 is involved in abnormal differentiation of T cells. CD274 to quantity of CD8+ T lymphocytes: mutant CD274 is increases number of CD8+ T cells. CTNNB1 to cell death: human CTNNB1 decreases death of cells. CTNNB1 to differentiation of T lymphocytes: active CTNNB1 increases the arrest in growth of thymocytes (thymic progenitors of T-cells). CTNNB1 to frequency of CD8+ T lymphocytes: active mutant CTNNB1 decreases differentiation thymocytes expressing CD4 and CD8 proteins. CTNNB1 to proliferation of B-lymphocyte derived cell lines: interference of CTNNB1 mRNA by siRNA decreases proliferation of pre-B cells (PD36 cells). CTNNB1 to quantity of CD8+ lymphocytes: activated mutant CTNNB1 in dendritic cells abnormally increases the number of CD8+ T cells in mouse spleen that are infected with vaccinia virus or Toxoplasma gondii. CTNNB1 to activation of CD4+ T lymphocytes: degradation of CTNNB1 protein is involved in activation of CD4+ T cells