Table 3 Laboratory parameters at the time of transplantation, ASCT-associated factors and hematological outcome
Group A (n = 238) | Group B (n = 67) | Group C (n = 50) | p-Value | |
|---|---|---|---|---|
Characteristics | ||||
Age (years) | 55 ± 9 | 57 ± 10 | 59 ± 9 | 0.018 |
BM infiltration (%) | 12 ± 16 | 19 ± 25 | 17 ± 21 | 0.097 |
β2 microglobulin (mg/L) | 2.1 ± 0.7 | 2.5 ± 1.0 | 5.8 ± 6.9 | < 0.001 |
Hemoglobin (g/dL) | 12.1 ± 1.6 | 11.8 ± 1.9 | 10.8 ± 1.4 | < 0.001 |
Calcium (mmol/L) | 2.3 ± 0.2 | 2.2 ± 0.2 | 2.2 ± 0.2 | 0.191 |
Creatinine (mg/dL) | 0.8 ± 0.2 | 0.9 ± 0.2 | 2.0 ± 1.6 | < 0.001 |
eGFR (ml/min/1.73m2) | 93 ± 21 | 82 ± 20 | 41 ± 15 | < 0.001 |
Renal function stage (%) | < 0.001 | |||
1 | 50.4 | 20.9 | – | |
2 | 49.6 | 79.1 | – | |
3a | – | – | 46.0 | |
3b | – | – | 32.0 | |
4 | – | – | 12.0 | |
5 | 10.0 | |||
Albumin (g/L) | 39 ± 5 | 39 ± 5 | 39 ± 6 | 0.719 |
LDH (U/L) | 178 ± 71 | 208 ± 131 | 180 ± 48 | 0.033 |
C-reactive protein (mg/dL) | 0.4 ± 0.9 | 0.8 ± 2.0 | 0.9 ± 2.8 | 0.035 |
Days to 0.5 × 109 ANC/L | 11 ± 1 | 11 ± 1 | 11 ± 1 | 0.128 |
Days to 1.0 × 109 ANC/L | 12 ± 1 | 12 ± 2 | 12 ± 4 | 0.259 |
Days to 20 × 109 platelets/L | 11 ± 2 | 11 ± 3 | 12 ± 3 | 0.001 |
Days to 50 × 109 platelets/L | 16 ± 6 | 16 ± 6 | 19 ± 11 | 0.008 |
Dialysis during ASCT (%) | – | 6 | 15 | < 0.001 |
Response to ASCT (%) | 0.300 | |||
CR | 41 | 49 | 36 | |
VGPR | 28 | 28 | 36 | |
PR | 26 | 21 | 17 | |
SD | 3 | – | 5 | |
PD | 2 | 2 | 7 | |