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Table 3 Laboratory parameters at the time of transplantation, ASCT-associated factors and hematological outcome

From: Impact of renal impairment on outcomes after autologous stem cell transplantation in multiple myeloma: a multi-center, retrospective cohort study

  Group A (n = 238) Group B (n = 67) Group C (n = 50) p-Value
Characteristics
Age (years) 55 ± 9 57 ± 10 59 ± 9 0.018
BM infiltration (%) 12 ± 16 19 ± 25 17 ± 21 0.097
β2 microglobulin (mg/L) 2.1 ± 0.7 2.5 ± 1.0 5.8 ± 6.9 < 0.001
Hemoglobin (g/dL) 12.1 ± 1.6 11.8 ± 1.9 10.8 ± 1.4 < 0.001
Calcium (mmol/L) 2.3 ± 0.2 2.2 ± 0.2 2.2 ± 0.2 0.191
Creatinine (mg/dL) 0.8 ± 0.2 0.9 ± 0.2 2.0 ± 1.6 < 0.001
eGFR (ml/min/1.73m2) 93 ± 21 82 ± 20 41 ± 15 < 0.001
Renal function stage (%)     < 0.001
 1 50.4 20.9  
 2 49.6 79.1  
 3a 46.0  
 3b 32.0  
 4 12.0  
 5    10.0  
Albumin (g/L) 39 ± 5 39 ± 5 39 ± 6 0.719
LDH (U/L) 178 ± 71 208 ± 131 180 ± 48 0.033
C-reactive protein (mg/dL) 0.4 ± 0.9 0.8 ± 2.0 0.9 ± 2.8 0.035
Days to 0.5 × 109 ANC/L 11 ± 1 11 ± 1 11 ± 1 0.128
Days to 1.0 × 109 ANC/L 12 ± 1 12 ± 2 12 ± 4 0.259
Days to 20 × 109 platelets/L 11 ± 2 11 ± 3 12 ± 3 0.001
Days to 50 × 109 platelets/L 16 ± 6 16 ± 6 19 ± 11 0.008
Dialysis during ASCT (%) 6 15 < 0.001
Response to ASCT (%)     0.300
 CR 41 49 36  
 VGPR 28 28 36  
 PR 26 21 17  
 SD 3 5  
 PD 2 2 7  
  1. BM bone marrow, eGFR estimated glomerular filtration rate, LDH lactate dehydrogenase, ANC absolute neutrophil count, ASCT autologous stem cell transplantation, CR complete remission, VGPR very good partial remission, PR partial remission, SD stable disease, PD progressive disease
  2. p < 0.05: statistically significant