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Table 1 Patient characteristics at diagnosis; primary hematological treatment

From: Impact of renal impairment on outcomes after autologous stem cell transplantation in multiple myeloma: a multi-center, retrospective cohort study

 

Group A (n = 238)

Group B (n = 67)

Group C (n = 50)

p-Value

Characteristics

Sex (% male)

58

54

56

0.368

Age (years)

54 ± 9

56 ± 9

59 ± 9

0.003

Monoclonal heavy chain (%)

 IgG

58

45

48

0.103

 IgA

24

27

8

0.031

 IgM

1

–

2

0.505

 IgD

1

–

2

0.505

 IgE

–

2

0

0.116

 Free LC only

17

27

40

0.001

Kappa LC (%)

57

64

54

0.466

Osteolysis (%)

76

85

76

0.583

Clinical stage (ISS, %)

   

< 0.001

 I

48

18

14

 

 II

33

24

30

 

 III

12

51

54

 

BM infiltration (%)

46 ± 29

54 ± 29

55 ± 25

0.053

Therapy (%)

   

0.576

 Immuno-chemotherapy

79

75

74

 

 Chemotherapy only

21

25

26

 

Time between diagnosis and ASCT (months)

13 ± 18

10 ± 10

9 ± 7

0.145

Primary response (%)

   

0.607

 CR

16

21

17

 

 VGPR

34

24

34

 

 PR

44

52

40

 

 SD

3

2

6

 

 PD

4

2

2

 
  1. LC light chain, ISS international staging system, BM bone marrow, CR complete remission, VGPR very good partial remission, PR partial remission, SD stable disease, PD progressive disease
  2. p < 0.05: statistically significant
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BMC Cancer

ISSN: 1471-2407

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