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Table 4 Overall survival analysis based on clinicopathological characteristics, biomarker status and P38 expression

From: Co-expression of nuclear P38 and hormone receptors is prognostic of good long-term clinical outcome in primary breast cancer and is linked to upregulation of DNA repair

Characteristic Univariate analysis Multivariate analysis
HR 95% CI p HR 95% CI p
p-P38 low reference reference
high 0.735 0.617–0.875 0.001 * 0.796 0.662–0.957 0.015 *
NPI good/medium reference reference
poor 2.465 2.054–2.959 < 0.001 * 2.120 1.731–2.596 < 0.001 *
VI negative or suspected reference reference
positive (definite) 1.436 1.225–1.683 < 0.001 * 1.161 0.973–1.384 0.097
ER negative reference n/a
positive 0.917 0.764–1.100 0.350    
PR negative reference reference
positive 0.711 0.607–0.832 < 0.001 * 0.830 0.703–0.980 0.028 *
HER2 negative reference reference
positive 1.722 1.393–2.128 < 0.001 * 1.486 1.191–1.856 < 0.001 *
  1. HR hazard ratio for death (all causes), CI confidence interval, ER/PR oestrogen/progesterone receptor status (by immunohistochemistry)
  2. *p value in bold type indicates statistically significant results (p < 0.05). NPI = Nottingham Prognostic Index; VI = vascular invasion; p-P38 = nuclear phosphorylated P38