BMC Cancer

Table 3 Nuclear p-P38 is associated with DNA repair markers

From: Co-expression of nuclear P38 and hormone receptors is prognostic of good long-term clinical outcome in primary breast cancer and is linked to upregulation of DNA repair

Variable		nuclear p-P38
Variable		negative / low		high		p
nuclear BRCA1	negative	402	(85.4%)	69	(14.6%)	< 0.001 ^*
nuclear BRCA1	positive	365	(63.6%)	209	(36.4%)	< 0.001 ^*
nuclear BRCA2	negative	540	(72.0%)	210	(28.0%)	0.393
nuclear BRCA2	positive	44	(66.7%)	22	(33.3%)	0.393
PARP1	negative	346	(75.4%)	113	(24.6%)	0.074
PARP1	positive	373	(70.1%)	159	(29.9%)	0.074
cleaved PARP1	negative	114	(85.7%)	19	(14.3%)	< 0.001 ^*
cleaved PARP1	positive	563	(71.5%)	224	(28.5%)	< 0.001 ^*
nuclear RAD51	negative	327	(82.4%)	70	(17.6%)	< 0.001 ^*
nuclear RAD51	positive	184	(62.8%)	109	(37.2%)	< 0.001 ^*
TP53	negative	636	(70.6%)	265	(29.4%)	0.337
TP53	positive	268	(73.4%)	97	(26.6%)	0.337

^*p value in bold type indicates statistical significance (p < 0.05, by Χ² test)

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ISSN: 1471-2407

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