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Table 3 Nuclear p-P38 is associated with DNA repair markers

From: Co-expression of nuclear P38 and hormone receptors is prognostic of good long-term clinical outcome in primary breast cancer and is linked to upregulation of DNA repair

Variable nuclear p-P38
negative / low high p
nuclear BRCA1 negative 402 (85.4%) 69 (14.6%) < 0.001 *
positive 365 (63.6%) 209 (36.4%)
nuclear BRCA2 negative 540 (72.0%) 210 (28.0%) 0.393
positive 44 (66.7%) 22 (33.3%)
PARP1 negative 346 (75.4%) 113 (24.6%) 0.074
positive 373 (70.1%) 159 (29.9%)
cleaved PARP1 negative 114 (85.7%) 19 (14.3%) < 0.001 *
positive 563 (71.5%) 224 (28.5%)
nuclear RAD51 negative 327 (82.4%) 70 (17.6%) < 0.001 *
positive 184 (62.8%) 109 (37.2%)
TP53 negative 636 (70.6%) 265 (29.4%) 0.337
positive 268 (73.4%) 97 (26.6%)
  1. *p value in bold type indicates statistical significance (p < 0.05, by Χ2 test)