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Fig. 6 | BMC Cancer

Fig. 6

From: The hypermethylation of p16 gene exon 1 and exon 2: potential biomarkers for colorectal cancer and are associated with cancer pathological staging

Fig. 6

p16 protein expression in CRC tissues by immunohistochemistry (IHC) and its association with p16 exon 1/2 methylation level. a Example of high p16 expression in adjacent normal tissue. b Example of high p16 expression in a CRC tissue without aberrant hypermethylation in both exon 1 and exon 2. Example of moderate p16 expression in a CRC tissue with aberrant hypermethylation in either exon 1 (c) or exon 2 (d). e Example of negative p16 expression in a CRC tissue with aberrant hypermethylation in both exon 1 and exon 2. f/g The correlation analysis of p16 protein expression and p16 exon 1/2 methylation level

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BMC Cancer

ISSN: 1471-2407

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