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Table 4 Univariable association of microRNAs with aging biomarkers at inclusion

From: Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy

MicroRNAa Telomere length IL-6 IL-10 IGF-1 TNFα MCP-1 RANTES
miR-20a −0.027 (0.8250) −0.131 (0.2208) − 0.141 (0.1979) −0.045 (0.6762) − 0.101 (0.3474) −0.045 (0.6743) − 0.052 (0.6273)
miR-30b −0.169 (0.1587) − 0.268 (0.0111) −0.166 (0.1291) 0.040 (0.7078) 0.049 (0.6479) −0.168 (0.1165) 0.057 (0.5987)
miR-34a −0.233 (0.0509) 0.057 (0.5962) −0.134 (0.2198) −0.104 (0.3306) 0.099 (0.3551) 0.184 (0.0835) −0.018 (0.8669)
miR-106b 0.228 (0.0559) −0.281 (0.0075) −0.096 (0.3841) 0.118 (0.2721) −0.310 (0.0031) − 0.288 (0.0062) 0.174 (0.1033)
miR-191 0.025 (0.8351) −0.304 (0.0038) −0.054 (0.6222) 0.015 (0.8891) −0.101 (0.3478) − 0.387 (0.0002) 0.074 (0.4878)
miR-301a −0.038 (0.7507) −0.340 (0.0011) − 0.070 (0.5236) 0.098 (0.3604) − 0.208 (0.0505) −0.328 (0.0017) 0.029 (0.7846)
miR-320b −0.234 (0.0492) 0.132 (0.2166) 0.171 (0.1181) −0.144 (0.1771) 0.396 (0.0001) 0.252 (0.0171) 0.040 (0.7115)
miR-374a −0.207 (0.0830) −0.337 (0.0012) − 0.248 (0.0221) 0.0003 (0.9777) − 0.024 (0.8250) −0.231 (0.0294) 0.192 (0.0713
miR-378a 0.018 (0.8842) 0.302 (0.0040) 0.153 (0.1620) −0.015 0.8866) 0.151 (0.1568) 0.295 (0.0051) −0.222 (0.0365)
  1. In each cell are displayed the Spearman’s correlation coefficient, and according p-value in parentheses
  2. p-values < 0.05 are marked in bold
  3. amiR-34a, miR-320b and miR-378a were previously shown to increase with aging; miR-20a, miR-30b, miR-106b, miR-191, miR-301a and miR-374a were previously shown to decrease with aging