Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy

Table 3 Independent predictors of chronological age and clinical/biological aging markers at inclusion

Response variable	Independent Predictor(s) ^c	Slope^a Odds Ratio^b	95%CI	p-value
Calendar age ^a	miR-301a	−2.371	(−3.700; −1.042)	0.0006
BALDUCCI ^b	–	–	–	–
LOFS ^a	miR-320b	− 0.623	(− 1.187; − 0.059)	0.0308
LOFS ^a	miR-374a	0.940	(0.396; 1.483)	0.0009
G8-total ^a	miR-106b	−1.145	(−2.082; − 0.209)	0.0171
	miR-191	− 1.461	(− 2.478; − 0.444)	0.0054
	miR-320b	− 0.776	(− 1.461; − 0.092)	0.0266
	miR-374a	1.209	(0.436; 1.982)	0.0026
fTRST ^b	miR-301a	0.487	(0.254; 0.934)	0.0302
Telomere length ^a	miR-320b	−0.095	(− 0.170; − 0.021)	0.0131
IL-6 ^a	miR-106b	−0.338	(−0.603; − 0.072)	0.0133
	miR-374a	− 0.294	(− 0.497; − 0.090)	0.0053
	miR-378a	0.301	(0.011; 0.591)	0.0418
IL-10 ^a	–	–	–	–
IGF-1 ^a	–	–	–	–
TNFα ^a	miR-320b	0.193	(0.040; 0.345)	0.0140
MCP-1 ^a	miR-301a	−0.180	(− 0.320; − 0.040)	0.0121
MCP-1 ^a	miR-378a	0.269	(0.098; 0.441)	0.0025
RANTES ^a	miR-378a	−0.390	(− 0.736; − 0.045)	0.0271

^aContinuous variable; slope indicates mean change in response variable for a 1-unit increase of miRNA values. Slope > 0 indicates positive association; slope < 0 indicates inverse correlation
^bOrdinal variable; odds ratio > 1 indicates increase in response variable with increased miRNA value (positive association); odds ratio < 1 indicates decrease in response variable with increased miRNA value (negative association)
^cmiR-34a, miR-320b and miR-378a were previously shown to increase with aging; miR-20a, miR-30b, miR-106b, miR-191, miR-301a and miR-374a were previously shown to decrease with aging

ISSN: 1471-2407