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Table 3 Independent predictors of chronological age and clinical/biological aging markers at inclusion

From: Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy

Response variable Independent
Predictor(s) c
Slopea
Odds Ratiob
95%CI p-value
Calendar age a miR-301a −2.371 (−3.700; −1.042) 0.0006
BALDUCCI b
LOFS a miR-320b − 0.623 (− 1.187; − 0.059) 0.0308
miR-374a 0.940 (0.396; 1.483) 0.0009
G8-total a miR-106b −1.145 (−2.082; − 0.209) 0.0171
miR-191 − 1.461 (− 2.478; − 0.444) 0.0054
miR-320b − 0.776 (− 1.461; − 0.092) 0.0266
miR-374a 1.209 (0.436; 1.982) 0.0026
fTRST b miR-301a 0.487 (0.254; 0.934) 0.0302
Telomere length a miR-320b −0.095 (− 0.170; − 0.021) 0.0131
IL-6 a miR-106b −0.338 (−0.603; − 0.072) 0.0133
miR-374a − 0.294 (− 0.497; − 0.090) 0.0053
miR-378a 0.301 (0.011; 0.591) 0.0418
IL-10 a
IGF-1 a
TNFα a miR-320b 0.193 (0.040; 0.345) 0.0140
MCP-1 a miR-301a −0.180 (− 0.320; − 0.040) 0.0121
miR-378a 0.269 (0.098; 0.441) 0.0025
RANTES a miR-378a −0.390 (− 0.736; − 0.045) 0.0271
  1. aContinuous variable; slope indicates mean change in response variable for a 1-unit increase of miRNA values. Slope > 0 indicates positive association; slope < 0 indicates inverse correlation
  2. bOrdinal variable; odds ratio > 1 indicates increase in response variable with increased miRNA value (positive association); odds ratio < 1 indicates decrease in response variable with increased miRNA value (negative association)
  3. cmiR-34a, miR-320b and miR-378a were previously shown to increase with aging; miR-20a, miR-30b, miR-106b, miR-191, miR-301a and miR-374a were previously shown to decrease with aging