Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy

Table 1 Evolution of microRNAs over time in CTG

MicroRNA^a	Inclusion versus 3 months			Inclusion versus 1 year			Study arm by time interaction^c
MicroRNA^a	Mean difference^b	95%CI	p-value	Mean difference^b	95%CI	p-value	p-value
miR-20a	−0.52	(−1.05, 0.01)	0.0537	−0.22	(−0.75, 0.31)	0.4042	0.0898
miR-30b	−0.39	(−0.60, − 0.18)	0.0003	−0.22	(− 0.42, − 0.02)	0.0319	0.0987
miR-34a	0.76	(0.25, 1.26)	0.0039	0.60	(0.18, 1.01)	0.0054	0.9884
miR-106b	0.03	(−0.17, 0.23)	0.7671	0.18	(0.00, 0.37)	0.0497	0.0240
miR-191	−0.09	(− 0.32, 0.15)	0.4669	− 0.27	(− 0.51, − 0.03)	0.0272	0.2045
miR-301a	− 0.11	(− 0.30, 0.09)	0.2673	−0.15	(− 0.39, 0.09)	0.2280	0.6222
miR-320b	0.10	(−0.15, 0.34)	0.4377	−0.01	(−0.22, 0.20)	0.9337	0.4120
miR-374a	−0.28	(−0.55, − 0.01)	0.0394	−0.12	(− 0.38, 0.13)	0.3470	0.2125
miR-378a	−0.02	(−0.21, 0.17)	0.8168	0.01	(−0.15, 0.16)	0.9413	0.6858

^amiR-34a, miR-320b and miR-378a were previously shown to increase with aging; miR-20a, miR-30b, miR-106b, miR-191, miR-301a and miR-374a were previously shown to decrease with aging
^bmiRNA normalized relative quantities were log2-transformed prior to statistical analysis; log2 values were subtracted to calculate mean differences between time points
^cSignificant interaction indicates different miRNA evolution in CTG as compared to CG
p-values < 0.05 are marked in bold

ISSN: 1471-2407