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Table 1 Evolution of microRNAs over time in CTG

From: Age-related microRNAs in older breast cancer patients: biomarker potential and evolution during adjuvant chemotherapy

MicroRNAa Inclusion versus 3 months Inclusion versus 1 year Study arm by time interactionc
Mean differenceb 95%CI p-value Mean differenceb 95%CI p-value p-value
miR-20a −0.52 (−1.05, 0.01) 0.0537 −0.22 (−0.75, 0.31) 0.4042 0.0898
miR-30b −0.39 (−0.60, − 0.18) 0.0003 −0.22 (− 0.42, − 0.02) 0.0319 0.0987
miR-34a 0.76 (0.25, 1.26) 0.0039 0.60 (0.18, 1.01) 0.0054 0.9884
miR-106b 0.03 (−0.17, 0.23) 0.7671 0.18 (0.00, 0.37) 0.0497 0.0240
miR-191 −0.09 (− 0.32, 0.15) 0.4669 − 0.27 (− 0.51, − 0.03) 0.0272 0.2045
miR-301a − 0.11 (− 0.30, 0.09) 0.2673 −0.15 (− 0.39, 0.09) 0.2280 0.6222
miR-320b 0.10 (−0.15, 0.34) 0.4377 −0.01 (−0.22, 0.20) 0.9337 0.4120
miR-374a −0.28 (−0.55, − 0.01) 0.0394 −0.12 (− 0.38, 0.13) 0.3470 0.2125
miR-378a −0.02 (−0.21, 0.17) 0.8168 0.01 (−0.15, 0.16) 0.9413 0.6858
  1. amiR-34a, miR-320b and miR-378a were previously shown to increase with aging; miR-20a, miR-30b, miR-106b, miR-191, miR-301a and miR-374a were previously shown to decrease with aging
  2. bmiRNA normalized relative quantities were log2-transformed prior to statistical analysis; log2 values were subtracted to calculate mean differences between time points
  3. cSignificant interaction indicates different miRNA evolution in CTG as compared to CG
  4. p-values < 0.05 are marked in bold