Characteristic | Univariate analysis Multivariate analysis | ||||||
---|---|---|---|---|---|---|---|
n | p | Mean RFS | 95% CI for RFS | p | Exp (B) | 95% CI for Exp (B) | |
Estrogen receptor status | 177 | 0.090 | |||||
Progesterone receptor status | 177 | 0.176 | |||||
Histological grade | 174 | 0.831 | |||||
Ki-67 proliferation index | 177 | 0.171 | |||||
Histological type (lobular/ductal) | 168 | 0.774 | |||||
Lymph nodal status pN+ (vs pN0) | 169 | 0.000*** | 6.7 (8.4) | 5.9 (8.0) – 7.5 (8.7) | 0.002** | 3.486 | 1.608, 7.555 |
Tumor size TNM stage ≥ pT3 (vs < pT3) | 172 | 0.000*** | 4.2 (7.9) | 2.3 (7.5) – 6.2 (8.3) | 0.001*** | 4.016 | 1.703, 9.468 |
Patient age at diagnosis | 177 | 0.118 | |||||
Menopausal status | 176 | 0.082 | |||||
Cytokeratin 5/14 expression | 167 | 0.447 | |||||
Basal phenotype (CK5/14+, ER-) | 167 | 0.955 | |||||
Total cellular HER3 low (vs high) | 177 | 0.004** | 6.3 (8.0) | 5.3 (7.6) – 7.3 (8.4) | 0.020* | 2.305 | 1.143, 4.648 |
Membranous HER3 low (vs high) | 177 | 0.025* | 6.6 (7.9) | 5.6 (7.4) – 7.7 (8.3) | |||
Cytoplasmic HER3 low (vs high) | 177 | 0.010* | 5.9 (7.8) | 4.2 (7.4) – 7.6 (8.2) | |||
NEDD4–1 expression | 145 | 0.261 | |||||
NRDP1 nuclear expression | 145 | 0.689 | |||||
NRDP1 cytoplasmic expression | 145 | 0.711 |