Table 5 Associations between HER3 protein expression and clinicopathological characteristics

HER2 status

0.615

0.990

0.882

 Negative

85.8

83.8

84.6

84.7

84.2

84.9

 Positive

14.2

16.2

15.4

15.3

15.8

15.1

Estrogen receptor status

0.057

0.280

0.839

0.013*

0.376

0.104

 Negative

23.6

15.1

30.8

18.7

18.4

19.5

54.3

31.7

46.7

35.2

46.5

32.8

 Positive

76.4

84.9

69.2

81.3

81.6

80.5

45.7

68.3

53.3

64.8

53.5

67.2

Progesterone receptor status

0.002**

0.368

0.443

0.888

0.882

0.716

 Negative

43.2

26.4

46.2

34.0

38.2

33.3

57.1

58.5

60.0

58.0

55.8

59.0

 Positive

56.8

73.6

53.8

66.0

61.8

66.7

42.9

41.5

40.0

42.0

44.2

41.0

Triple-negativity (HER2-/ER-/PR-)

0.000***

0.099

0.798

 No

83.8

96.2

76.9

90.8

89.5

90.5

 Yes

16.2

3.8

23.1

9.2

10.5

9.5

Histological grade

0.121

0.855

0.705

0.435

0.767

0.956

 I-II

72.8

81.4

75.0

77.3

75.4

77.8

28.6

22.3

26.7

23.3

23.3

23.6

 III

27.2

18.6

25.0

22.7

24.6

22.2

71.4

77.7

73.3

76.7

76.7

76.4

Ki-67 proliferation index

0.597

0.985

0.852

0.475

0.213

0.658

 Low

73.4

70.2

71.4

71.7

72.7

71.4

22.9

17.6

6.7

19.8

20.9

17.9

 High

26.6

29.8

28.6

28.3

27.3

28.6

77.1

82.4

93.3

80.2

79.1

82.1

Histological type

0.629

0.359

0.204

0.055

0.940

0.960

 Ductal

55.5

58.2

69.2

56.4

63.2

54.8

85.3

94.8

93.3

92.8

92.7

92.9

 Lobular

44.5

41.8

30.8

43.6

36.8

45.2

14.7

5.2

6.7

7.2

7.3

7.1

Lymph nodal status

0.531

0.637

0.716

0.232

0.169

0.035*

 Negative pN0

58.3

61.9

66.7

59.9

62.0

59.5

65.7

54.5

40.0

58.4

42.9

61.4

 Positive pN+

41.7

38.1

33.3

40.1

38.0

40.5

34.3

45.5

60.0

41.6

57.1

38.6

Tumor size (TNM stage)

0.840

0.921

0.781

0.173

0.001***

0.368

 pT1-pT2

91.9

91.3

92.3

91.5

90.8

91.8

88.6

94.9

73.3

95.5

90.7

94.6

 pT3-pT4

8.1

8.7

7.7

8.5

9.2

8.2

11.4

5.1

26.7

4.5

9.3

5.4

Tumor size (cm)

0.003**

0.834

0.357

0.643

0.014*

0.143

 <2cm

21.6

42.7

28.6

32.4

26.7

34.1

51.7

46.9

15.4

51.2

37.1

51.4

 ≥2cm

78.4

57.3

71.4

67.6

73.3

65.9

48.3

53.1

84.6

48.8

62.9

48.6

Patient age at diagnosis

0.726

0.624

0.217

0.069

0.000***

0.156

 <50 years

21.6

20.0

15.4

21.0

15.8

22.4

31.4

17.6

60.0

16.7

27.9

17.9

 ≥50 years

78.4

80.0

84.6

79.0

84.2

77.6

68.6

82.4

40.0

83.3

72.1

82.1

Cytokeratin 5/14 expression

0.583

0.561

0.006**

 Negative

85.3

88.7

92.9

87.6

76.2

92.0

 Positive

14.7

11.3

7.1

12.4

23.8

8.0

Basal phenotype (CK5/14+, ER-)

0.191

0.801

0.001***

 No

85.3

92.5

92.9

90.8

78.6

95.2

 Yes

14.7

7.5

7.1

9.2

21.4

4.8