TROG 15.03 phase II clinical trial of Focal Ablative STereotactic Radiosurgery for Cancers of the Kidney - FASTRACK II

Table 3 Organ at Risk Constraints

Organ	Parameter	Dose / Fractionation
Organ	Parameter	26Gy/1Fx	42Gy/3Fx
Spinal canal	Maximum dose	0.03 cc < 12Gy point dose	0.03 cc < 18Gy point dose
Skin (5 mm subcutis)	Maximum Dose (1.5 cc)	< 18Gy	< 30Gy
Small Bowel	Maximum Dose / Volume	0.03 cc <26Gy 5cc < 22.5Gy Aim for <13Gy to full circumference of small bowel loop	0.03 cc < 30Gy 30cc ≤ 12.5Gy
Small Bowel	Maximum dose covering full circumference of bowel wall	≤12.5Gy	≤22.5Gy
Large Bowel	Maximum Dose (1.5 cc)	ALARA, aim for <26Gy	ALARA, aim for <42Gy
Stomach	Maximum Dose Maximum Volume	1.5 cc < 15.4Gy 5 cc ≤ 22.5Gy	0.03 cc < 30 Gy 5 cc ≤ 22.5Gy
Liver	Mean dose, Maximum Volume	No constraint, but mean dose and dose to 700 cc to be documented	700 cc < 15Gy
Ipsilateral kidney minus ITV	Maximum Dose (1.5 cc), V10Gy	ALARA: Minimise volume of high dose regions (> 50% isodose)^a	ALARA: Minimise volume of high dose regions (> 50% isodose)
Contralateral Kidney	V10Gy	≤33%	≤33%

^a Ipsilateral Kidney minus ITV should adhere to the ALARA principle. In particular, investigators should focus on minimising high dose regions (> 50% isodose) outside the ITV but within the ipsilateral kidney

ISSN: 1471-2407