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Table 3 Univariate and multivariate Cox regression analysis for time to treatment (TTT) and overall survival (OS) in 102 subjects with chronic lymphocytic leukemia

From: NDRG2 mRNA levels and miR-28-5p and miR-650 activity in chronic lymphocytic leukemia

Variables

Univariate analysis (Kaplan-Meier)

Multivariate analysis

P-value

HR(95%CI)

P-value

TTT

 Age >60 y

0.842

0.83 (0.46–1.49)

0.530

 Sex (male)

0.821

1.52 (0.85–2.71)

0.159

 Binet B/C stage

<0.001

2.48 (1.27–4.84)

0.008

 ALC ≥50×109/L

0.977

0.90 (0.50–1.63)

0.721

 LDH>ULN

0.767

0.72 (0.36–1.43)

0.348

 β2-MG>ULN

0.095

1.49 (0.81–2.74)

0.204

 CD38 (≥30%)

0.164

1.01 (0.55–1.84)

0.988

 ZAP-70 (≥20%)

0.308

0.89 (0.50–1.59)

0.692

 IGHV unmutated

<0.001

1.68 (0.97–2.92)

0.067

 p53 aberration

<0.001

2.46 (1.19–5.09)

0.015

 NDRG2 expression (high)

0.001

2.01 (1.11–3.64)

0.022

OS

 Age >60 y

0.700

0.89 (0.34–2.35)

0.814

 Sex (male)

0.633

1.33 (0.51–3.48)

0.563

 Binet B/C stage

0.028

0.85 (0.22–3.33)

0.814

 ALC ≥50×109/L

0.524

0.70 (0.22–2.25)

0.549

 LDH>ULN

0.071

1.81 (0.52–6.26)

0.349

 β2-MG>ULN

0.813

1.29 (0.46–3.59)

0.628

 CD38 (≥30%)

0.002

2.01 (0.79–5.13)

0.143

 ZAP-70 (≥20%)

0.079

1.31 (0.44–3.89)

0.632

 IGHV unmutated

<0.001

3.03 (1.16–7.95)

0.024

 p53 aberration

<0.001

3.95 (1.34–11.67)

0.013

 NDRG2 expression (high)

<0.001

3.43 (1.06–11.14)

0.040