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Table 3 Univariate and multivariate Cox regression analysis for time to treatment (TTT) and overall survival (OS) in 102 subjects with chronic lymphocytic leukemia

From: NDRG2 mRNA levels and miR-28-5p and miR-650 activity in chronic lymphocytic leukemia

Variables Univariate analysis (Kaplan-Meier) Multivariate analysis
P-value HR(95%CI) P-value
TTT
 Age >60 y 0.842 0.83 (0.46–1.49) 0.530
 Sex (male) 0.821 1.52 (0.85–2.71) 0.159
 Binet B/C stage <0.001 2.48 (1.27–4.84) 0.008
 ALC ≥50×109/L 0.977 0.90 (0.50–1.63) 0.721
 LDH>ULN 0.767 0.72 (0.36–1.43) 0.348
 β2-MG>ULN 0.095 1.49 (0.81–2.74) 0.204
 CD38 (≥30%) 0.164 1.01 (0.55–1.84) 0.988
 ZAP-70 (≥20%) 0.308 0.89 (0.50–1.59) 0.692
 IGHV unmutated <0.001 1.68 (0.97–2.92) 0.067
 p53 aberration <0.001 2.46 (1.19–5.09) 0.015
NDRG2 expression (high) 0.001 2.01 (1.11–3.64) 0.022
OS
 Age >60 y 0.700 0.89 (0.34–2.35) 0.814
 Sex (male) 0.633 1.33 (0.51–3.48) 0.563
 Binet B/C stage 0.028 0.85 (0.22–3.33) 0.814
 ALC ≥50×109/L 0.524 0.70 (0.22–2.25) 0.549
 LDH>ULN 0.071 1.81 (0.52–6.26) 0.349
 β2-MG>ULN 0.813 1.29 (0.46–3.59) 0.628
 CD38 (≥30%) 0.002 2.01 (0.79–5.13) 0.143
 ZAP-70 (≥20%) 0.079 1.31 (0.44–3.89) 0.632
 IGHV unmutated <0.001 3.03 (1.16–7.95) 0.024
 p53 aberration <0.001 3.95 (1.34–11.67) 0.013
NDRG2 expression (high) <0.001 3.43 (1.06–11.14) 0.040