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Table 2 Univariate analysis of clinicopathological parameters and inflammatory biomarkers influencing prognosis

From: High postoperative monocyte indicates inferior Clinicopathological characteristics and worse prognosis in lung adenocarcinoma or squamous cell carcinoma after lobectomy

Category

Variables

Disease-free survival

Overall survival

HR (95% CI)

P a

HR (95% CI)

P a

Gender

Male

Reference

 

Reference

 

Female

0.963(0.716–1.295)

0.801

0.841(0.581–1.216)

0.358

Age

Per year

1.008(0.993–1.022)

0.311

1.023(1.004–1.042)

0.017

Smoking history

Yes

Reference

 

Reference

 

No

1.009(0.756–1.348)

0.950

0.838(0.585–1.202)

0.337

Location

Left superior

Reference

 

Reference

 

Left inferior

0.989(0.634–1.545)

0.962

1.492(0.870–2.560)

0.146

Right superior

0.875(0.604–1.267)

0.479

1.205(0.758–1.916)

0.431

Right middle

1.263(0.785–2.031)

0.335

1.486(0.817–2.700)

0.194

Right inferior

0.655(0.410–1.047)

0.077

0.899(0.506–1.596)

0.715

Procedure

VATS

Reference

 

Reference

 

Thoracotomy

1.455(1.093–1.937)

0.010

1.760(1.236–2.505)

0.002

T stage

T1

Reference

 

Reference

 

T2

1.219(0.833–1.783)

0.309

1.268(0.775–2.072)

0.344

T3

1.559(0.945–2.573)

0.082

2.453(1.361–4.421)

0.003

T4

1.376(0.609–3.111)

0.443

1.602(0.601–4.271)

0.346

N stage

N0

Reference

 

Reference

 

N1

2.467(1.695–3.592)

< 0.001

2.869(1.833–4.491)

< 0.001

N2

3.349(2.414–4.647)

< 0.001

3.442(2.306–5.139)

< 0.001

Stage

I

Reference

 

Reference

 

II

1.847(1.273–2.679)

0.001

2.342(1.460–3.757)

< 0.001

IIIA

3.163(2.260–4.428)

< 0.001

4.078(2.658–6.258)

< 0.001

Histological type

Squamous carcinoma

Reference

 

Reference

 

Adenocarcinoma

2.994(1.418–6.113)

0.014

1.465(0.712–3.018)

0.300

Differentiation

Well

Reference

 

Reference

 

Moderate

6.446(0.899–46.191)

0.064

3.869(0.538–27.831)

0.179

Poor

7.172(0.996–51.643)

0.050

4.340(0.599–31.455)

0.146

Preoperative monocyte

< 0.375

Reference

 

Reference

 

≥0.375

1.391(1.047–1.849)

0.023

1.490(1.053–2.109)

0.024

Postoperative monocyte

<0.845

Reference

 

Reference

 

≥0.845

3.974(2.956–5.342)

< 0.001

3.826(2.662–5.499)

< 0.001

  1. T stage tumor, N stage node, VATS Video-assistant thoracoscopic surgery, HR hazard ratio, CI confidence interval
  2. aP value of univariate analysis. P < 0.05 was considered statistically significant
  3. The bold data means the data has statistically significance
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BMC Cancer

ISSN: 1471-2407

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