Table 3 Meta analysis of miR-20a as an independent prognostic indicator for patients of various caricinomas
From: MiR-20a, a novel promising biomarker to predict prognosis in human cancer: a meta-analysis
| Â | No. of studies | No. of patients | Pooled HR(95%CI) | Meta regression | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
Fixed | Random | p-value | I2 | p-value | |||
Overall | 7 | 1252 | 1.52(1.24,1.85) | 1.07(0.47,2.44) | Â | 93.40% | 0.000 |
Population | 0.020 | Â | Â | ||||
 Chinese | 6 | 1163 | 1.59(1.29,1.94) | 1.24(0.52,2.96) |  | 94.10% | 0.000 |
 Italian | 1 | 89 | 0.37(0.11,1.17) | 0.37(0.11,1.17) |  | – | – |
Sample Size | 0.011 | Â | Â | ||||
  ≥ 150 | 3 | 892 | 2.16(1.62,2.88) | 1.82(0.38,8.67) |  | 95.90% | 0.000 |
  < 150 | 4 | 360 | 1.09(0.82,1.44) | 0.70(0.25,1.96) |  | 90.00% | 0.000 |
NOS Scores | 0.107 | Â | Â | ||||
  ≥ 8 | 4 | 894 | 2.19(1.74,2.77) | 2.03(0.89,4.63) |  | 90.20% | 0.000 |
  < 8 | 3 | 358 | 0.52(0.35,0.77) | 0.48(0.13,1.76) |  | 90.80% | 0.000 |
Specimen | 0.040 | Â | Â | ||||
 Blood | 3 | 367 | 1.87(1.47,2.37) | 1.86(1.45,2.40) |  | 9.60% | 0.331 |
 Tissues | 4 | 885 | 0.93(0.64,1.34) | 0.67(0.10,4.60) |  | 96.20% | 0.000 |
Tumor Category | 0.012 | Â | Â | ||||
 Gastrointestinal cancer | 2 | 609 | 2.41(1.77,3.28) | 3.53(0.70,17.81) |  | 95.20% | 0.000 |
 Non-gastrointestinal cancer | 5 | 643 | 1.09(0.84,1.42) | 0.64(0.47,2.44) |  | 92.70% | 0.000 |