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Table 3 Meta analysis of miR-20a as an independent prognostic indicator for patients of various caricinomas

From: MiR-20a, a novel promising biomarker to predict prognosis in human cancer: a meta-analysis

  No. of studies No. of patients Pooled HR(95%CI) Meta regression Heterogeneity
Fixed Random p-value I2 p-value
Overall 7 1252 1.52(1.24,1.85) 1.07(0.47,2.44)   93.40% 0.000
Population 0.020   
 Chinese 6 1163 1.59(1.29,1.94) 1.24(0.52,2.96)   94.10% 0.000
 Italian 1 89 0.37(0.11,1.17) 0.37(0.11,1.17)  
Sample Size 0.011   
  ≥ 150 3 892 2.16(1.62,2.88) 1.82(0.38,8.67)   95.90% 0.000
  < 150 4 360 1.09(0.82,1.44) 0.70(0.25,1.96)   90.00% 0.000
NOS Scores 0.107   
  ≥ 8 4 894 2.19(1.74,2.77) 2.03(0.89,4.63)   90.20% 0.000
  < 8 3 358 0.52(0.35,0.77) 0.48(0.13,1.76)   90.80% 0.000
Specimen 0.040   
 Blood 3 367 1.87(1.47,2.37) 1.86(1.45,2.40)   9.60% 0.331
 Tissues 4 885 0.93(0.64,1.34) 0.67(0.10,4.60)   96.20% 0.000
Tumor Category 0.012   
 Gastrointestinal cancer 2 609 2.41(1.77,3.28) 3.53(0.70,17.81)   95.20% 0.000
 Non-gastrointestinal cancer 5 643 1.09(0.84,1.42) 0.64(0.47,2.44)   92.70% 0.000
  1. Abbreviations: 95%CI 95% confidence interval, Fixed Fixed effects model, HR Hazard ratio, NOS Newcastle-Ottawa scale scores, Random Random pooling model