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Table 3 Multivariate model to predict DFS and OS in patients after potentially curative liver metastasectomy

From: Impact of CDX2 expression status on the survival of patients after curative resection for colorectal cancer liver metastasis

Features DFS OS
HR (95% CI) P value HR (95% CI) P value
CDX2 expression
 High 1 (reference)   1 (reference)  
 Low 1.64 (1.08–2.38) 0.02 2.41 (1.52–3.85) < 0.001
Sex
 Female 1 (reference)   1 (reference)  
 Male 0.96 (0.73–1.24) 0.74 0.94 (0.65–1.34) 0.74
Tumor grade
 Well 1 (reference)   1 (reference)  
 Mod 1.04 (0.73–1.47) 0.83 1.29 (0.79–2.10) 0.30
 Por 1.24 (0.68–2.28) 0.48 1.73 (0.73–4.04) 0.21
Pre- or post-operative chemotherapy
 No 1 (reference)   1 (reference)  
 Yes 0.92 (0.68–1.22) 0.55 1.58 (1.06–2.36) 0.02
Tumor location
 Right 1 (reference)   1 (reference)  
 Left 0.85 (0.62–1.17) 0.33 0.67 (0.44–1.01) 0.06
 Rectum 0.97 (0.71–1.37) 0.97 0.63 (0.68–1.05) 0.08
Liver metastasis
 Synchronous 1 (reference)   1 (reference)  
 Metachronous 0.59 (0.45–0.77) < 0.001 1.25 (0.88–1.79) 0.20
  1. Abbreviations: well Well differentiated, mod Moderately differentiated, por Poorly differentiated, HR Hazard ratio, OS Overall survival, DFS Disease-free survival