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Table 1 The main characteristics of included studies

From: Impact of tumor size on survival of patients with resected pancreatic ductal adenocarcinoma: a systematic review and meta-analysis

Reference Year Country N TS > 2.0 cm, n (%) TRPD/DP/TP R0 R, n (%) LNM, n (%) PNI, n (%) PTD, n (%) MOS (Months) 5-yr OS (%)
Meyer [9] 2000 Germany 91 67/86 (77.9) −/−/− 93 (100) 66 (72.5) 41 (45.1) 14 (16.3) 16.8 10.5
Ahmad [10] 2001 USA 116 70/94 (74.4) −/−/− 88 (75.8) 73 (62.9) 61 (52.5) 16 19
Kim [11] 2006 USA 70 50 (71.4) 68/2/0 40 (57.1) 46 (65.7) 26 (37.1) 21 19
Smith [12] 2008 UK 109 81 (74.3) 109/0/0 80 (73.3) 88 (80.7) 36 (33.0) 13.9
Chiang [13] 2009 Taiwan, 159 123 (77.3) −/−/− 114 (71.6) 95 (59.7) 32 (20.1) 12.5
Chang [14] 2009 Australia 365 281 (76.9) 295/70/0 233 (63.8) 217 (59.5) 256 (70.1) 98 (26.8) 16.8 11.4
Kato [15] 2009 Japan 176 148 (84.1) 176/0/0 115 (65.3) 123 (69.8) 145 (82.3) 11 (6.2) 9.9 12.3
Massucco [16] 2009 Italy 77 60 (77.9) 63/0/14 59 (76.6) 59 (76.6) 58 (75.3) 50 (64.9) 16.5
Bhatti [17] 2010 UK 84 78 (92.8) 84/0/0 49 (58.3) 56 (66.6) 24 (28.5) 22 13
de Jong [5] 2011 USA 1697 1279 (75.4) 1640/0/57 1213 (71.8) 1280 (75.4) 1126 (66.3) 649 (38.2) 18.3 21.2
Cannon [18] 2012 USA 245 213 (86.9) 220/20/0 184 (75.1) 72 (29.4) 18.3
Petermann [19] 2013 Switzerland 86 76 (88.3) 86/0/0 89 (68.6) 72 (83.7) 16.8
Yamada [20] 2013 Japan 390 312 (80.0) 288/71/31 277 (71.0)
Buc [21] 2014 France, 306 242/45/19 195 (72.5) 214 (71.3) 212 (83.8) 34 32
Elberm [22] 2015 UK 1070 1070/0/0 482 (45.9) 757 (70.7) 18.5
Iwagami [23] 2015 Japan 39 27 (69.2) −/−/− 14 (35.9) 34 (87.2) 3 (7.6)
Liu [24] 2015 USA 411 242 (58.9) 411/0/0 379 (92.2) 223 (54.3%) 150 (36.5)
Okumura [25] 2015 Japan 230 155/66/9 190 (82.6) 135 (58.7). 33 (14.3)
Yamamoto [26] 2015 Japan 195 156 (80.0) 123/61/11 138 (70.7) 145 (74.3) 108 (55.3) 27.1 34.5
Lin [27] 2016 China 233 189 (81.1) 233/0/0 196 (84.1) 161 (69.1) 147 (63.1) 19.0
Abe [28] 2017 Japan 355 273 (76.9) 215/98/22 282 (79.4) 223 (62.8) 282 (79.4) 137 (38.5)
Ansari [29] 2017 USA 15,398 12,725 (82.6) −/−/− 16.1
Chikamoto [30] 2017 Japan 138 66 (47.8) 138/0/0 46 (33.3) 10 (7.2)
Marchegiani [6] 2017 Italy, USA 1507 1183 (78.5) 1179/268/59 840 (55.7) 1149 (76.2) 1376 (91.3) 468 (31.1) 26.0
Kurata [31] 2017 Japan 90 41 (45.6) −/−/− 31 (34.4)
Le [32] 2017 USA 93 70/86 (81.3) 93/0/0 78 (84.7) 50 (53.8) 40.6
Watanabe [33] 2017 Japan 122 98 (87.5) 73/47/2 122 (100) 62 (55.3) 6 (4.9) 21 27
Yu [34] 2017 China 93 32 (34.4) −/−/− 89 (96.6) 49 (52.6) 52 (55.9) 36 (38.7)
  1. UK United Kingdom, PNI peri-neural invasion, TS tumor size, LNM lymph node metastasis, PTD poor tumor differentiation, MOS median overall survival, TR type of resection, PD pancreaticoduodenectomy, DP distal pancreatectomy, TP total pancreatectomy, R0 R R0 resection