Untargeted lipidomic features associated with colorectal cancer in a prospective cohort

BMC Cancer

Table 3 Untargeted features selected as predictors of case-control status

Feature ID	Observed m/z ^{a, b}	Ret. time (sec)	Fold change	p-value	Feature type ^c
235	391.2832	596.4	0.702	0.000261	R
4250	453.3592	605.5	0.753	0.001082	R
4294	467.3744	605.6	0.741	0.000569	R
5080	519.1965	595.9	1.308	0.000432	C
3207	531.1558	563.9	0.661	0.000468	C
6054	551.1781	563.9	0.404	0.001750	C
839	577.2698	620.6	1.370	0.000359	C
5749	882.6393	718.2	0.880	0.000168	I
14,963	907.4806	617.6	1.373	0.000133	R

m/z mass-to-charge ratio, p-value from the regression model (Eq. 2), C potentially causal feature, R potentially reactive feature, I indeterminate
^aObserved m/z values correspond to singly-charged negative ions
^bFeature selected by bootstrap LASSO and by being in the top 1% of features ranked by both the p-values from the case-control regression (Eq. 2) and the random forest variable importance measure
^cBased on regression of case-control difference on time to diagnosis (ttd, Fig. 2)

ISSN: 1471-2407