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Table 4 Concurrent Chemotherapy-Related Adverse Events

From: Efficacy and safety of concurrent anti-Cancer and anti-tuberculosis chemotherapy in Cancer patients with active Mycobacterium tuberculosis: a retrospective study

NCI-CTCa (Grade)

Patients

All

LC

CRC

Other

(n = 28)

(n = 13b)

(n = 10)

(n = 5)

Adverse event

1–2

≥3

1–2

≥3

1–2

≥3

1–2

≥3

Hematological toxicity, number of cases

 Leukocytopenia

7

8

4

6

3

1

2

1

 Neutropenia

5

14

1

9

2

3

2

2

 Anemia

20

2

9

2

8

0

3

0

 Thrombocytopenia

3

3

1

2

1

1

1

0

 Lymphopenia

13

10

4

8*

7

1

2

1

Non-hematological toxicity, number of cases

 AST/ALT elevation

12

0

4

0

6

0

2

0

 Interstitial pneumonitis

0

1c

0

1c

0

0

0

0

 Colitis

0

1d

0

0

0

0

0

1d

 Anaphylaxis

0

2e

0

0

0

2e

0

0

 Hemorrhage

1f

1g

1f

0

0

1g

0

0

  1. Abbreviations CRC colorectal cancer, LC lung cancer
  2. aNCI-CTC: National Cancer Institute Common Toxicity Criteria
  3. bIn two of 15 patients, laboratory data was lost
  4. cDeath caused by pemetrexed-induced pneumonitis
  5. dPseudomembranous colitis due to Clostridium difficile infection
  6. eOxaliplatin- and cetuximab-induced anaphylaxis
  7. fNasal bleeding
  8. gHemoptysis
  9. *: P < 0.005