NCI-CTCa (Grade) | Patients | |||||||
---|---|---|---|---|---|---|---|---|
All | LC | CRC | Other | |||||
(n = 28) | (n = 13b) | (n = 10) | (n = 5) | |||||
Adverse event | 1–2 | ≥3 | 1–2 | ≥3 | 1–2 | ≥3 | 1–2 | ≥3 |
Hematological toxicity, number of cases | ||||||||
 Leukocytopenia | 7 | 8 | 4 | 6 | 3 | 1 | 2 | 1 |
 Neutropenia | 5 | 14 | 1 | 9 | 2 | 3 | 2 | 2 |
 Anemia | 20 | 2 | 9 | 2 | 8 | 0 | 3 | 0 |
 Thrombocytopenia | 3 | 3 | 1 | 2 | 1 | 1 | 1 | 0 |
 Lymphopenia | 13 | 10 | 4 | 8* | 7 | 1 | 2 | 1 |
Non-hematological toxicity, number of cases | ||||||||
 AST/ALT elevation | 12 | 0 | 4 | 0 | 6 | 0 | 2 | 0 |
 Interstitial pneumonitis | 0 | 1c | 0 | 1c | 0 | 0 | 0 | 0 |
 Colitis | 0 | 1d | 0 | 0 | 0 | 0 | 0 | 1d |
 Anaphylaxis | 0 | 2e | 0 | 0 | 0 | 2e | 0 | 0 |
 Hemorrhage | 1f | 1g | 1f | 0 | 0 | 1g | 0 | 0 |