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Table 3 Association of recurrence free survivals with DNA methylation age

From: Decelerated DNA methylation age predicts poor prognosis of breast cancer

DNAm Age N Overall recurrence free survival Five-year recurrence free survival
HR (95% CI) a HR (95% CI) b HR (95% CI) c HR (95% CI) a HR (95% CI) b HR (95% CI) c
Continuous
 (Per ten year) 889 0.89 (0.81–0.98) 0.86 (0.77–0.96) 0.86 (0.76–0.97) 0.87 (0.78–0.98) 0.84 (0.75–0.95) 0.86 (0.75–0.98)
Categorical (quartile) d
 First 215 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
 Second 230 0.82 (0.48–1.39) 0.76 (0.44–1.31) 0.77 (0.43–1.36) 0.77 (0.43–1.36) 0.70 (0.39–1.25) 0.71 (0.39–1.31)
 Third 227 0.82 (0.49–1.37) 0.72 (0.42–1.23) 0.70 (0.39–1.29) 0.76 (0.43–1.36) 0.65 (0.36–1.17) 0.68 (0.36–1.32)
 Fourth 217 0.48 (0.25–0.90) 0.40 (0.21–0.78) 0.39 (0.19–0.80) 0.39 (0.19–0.80) 0.31 (0.15–0.66) 0.32 (0.14–0.74)
 P for trend 0.031 0.009 0.014 0.014 0.003 0.020
Categorical (First quartile and second-fourth quartile)
 First 215 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
 Second-Fourth 674 0.71 (0.46–1.08) 0.64 (0.41–1.00) 0.66 (0.39–1.09) 0.64 (0.40–1.02) 0.57 (0.35–0.93) 0.62 (0.35–1.07)
  1. aNo adjustment
  2. bAdjusted only for chronological age (continuous)
  3. cAdjusted for chronological age (continuous), race, clinical stage, Menopause Status, ER status, HER2 status and PAM50 subtype
  4. dPatients were divided into quartiles according to DNAm age. First quartile: 2.2–37.6; Second quartile: 37.7–49.8; Third quartile: 49.9–64.9; Fourth quartile: 65–157
  5. Significant ones are in boldface