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Table 2 Association of overall and five-year survival with DNA methylation age

From: Decelerated DNA methylation age predicts poor prognosis of breast cancer

DNAm Age N Overall survival Five-year survival
HR (95% CI) a HR (95% CI) b HR (95% CI) c HR (95% CI) a HR (95% CI) b HR (95% CI) c
Continuous
 (Per ten year) 1076 1.01 (0.94–1.08) 0.92 (0.85–1.00) 0.94 (0.86–1.02) 0.92 (0.84–1.01) 0.84 (0.75–0.93) 0.85 (0.76–0.96)
Categorical (quartile) d
 First 269 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
 Second 269 0.80 (0.51–1.26) 0.66 (0.42–1.05) 0.64 (0.39–1.04) 0.59 (0.34–1.03) 0.49 (0.28–0.85) 0.52 (0.29–0.92)
 Third 269 0.79 (0.51–1.24) 0.56 (0.35–0.89) 0.56 (0.34–0.93) 0.66 (0.39–1.12) 0.46 (0.27–0.78) 0.49 (0.27–0.87)
 Fourth 269 1.00 (0.66–1.53) 0.56 (0.35–0.90) 0.60 (0.36–1.04) 0.60 (0.34–1.03) 0.33 (0.18–0.59) 0.38 (0.20–0.72)
 P for trend 0.939 0.014 0.065 0.075 0.001 0.004
Categorical (First quartile and second-fourth quartile)
 First 269 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref) 1.00 (Ref)
 Second-Fourth 807 0.86 (0.61–1.22) 0.59 (0.41–0.86) 0.60 (0.40–0.91) 0.61 (0.41–0.93) 0.42 (0.27–0.65) 0.47 (0.29–0.76)
  1. aNo adjustment
  2. bAdjusted only for chronological age (continuous)
  3. cAdjusted for chronological age (continuous), race, clinical stage, menopause status, ER status, HER2 status and PAM50 subtype
  4. dPatients were divided into quartiles according to DNAm age. First quartile: 2.2–37.6; Second quartile: 37.7–49.8; Third quartile: 49.9–64.9; Fourth quartile: 65–157
  5. Significant ones are in boldface