Skip to main content

Table 1 Demographic and clinicopathological characteristics and the associations with DNA methylation age for 1076 female breast cancer patients (N, %)

From: Decelerated DNA methylation age predicts poor prognosis of breast cancer

Characteristics Total DNAm age (quartile)b P value a
First Second Third Fourth
Age (years)
  < 40 96 (8.9) 52 (19.3) 20 (7.4) 13 (4.8) 11 (4.1) < 0.01
 40–60 496 (46.1) 145 (53.9) 148 (55.0) 115 (42.8) 88 (32.7)
  > 60 484 (45.0) 72 (26.8) 101 (37.5) 141 (52.4) 170 (63.2)
Race
 African American 178 (16.5) 72 (26.8) 40 (14.9) 35 (13.0) 31 (11.5) < 0.01
 White or other 898 (83.5) 197 (73.2) 229 (85.1) 234 (87.0) 238 (88.5)
Menopausal status
 Premenopausal 229 (21.3) 80 (29.7) 57 (21.2) 54 (20.1) 38 (14.1) < 0.01
 Post-menopausal 736 (68.4) 153 (56.9) 185 (68.8) 187 (69.5) 211 (78.4)
 Unknown 111 (10.3) 36 (13.4) 27 (10.0) 28 (10.4) 20 (7.4)  
ER
 Negative 178 (16.6) 99 (36.8) 53 (19.7) 20 (7.4) 6 (2.2) < 0.01
 Positive 588 (54.6) 95 (35.3) 140 (52.0) 161 (59.9) 192 (71.4)
 Unknown 310 (28.8) 75 (27.9) 76 (28.3) 88 (32.7) 71 (26.4)  
PR
 Negative 251 (23.3) 122 (45.4) 67 (24.9) 36 (13.4) 26 (9.7) < 0.01
 Positive 512 (47.6) 70 (26.0) 126 (46.8) 145 (53.9) 171 (63.6)
 Unknown 313 (29.1) 77 (28.6) 76 (28.3) 88 (32.7) 72 (26.7)  
HER2
 Negative 644 (59.9) 156 (58.0) 162 (60.2) 155 (57.6) 171 (63.5) 0.33
 Equivocal/positive 118 (11.0) 37 (13.7) 31 (11.5) 24 (9.0) 26 (9.7)
 Unknown 314 (29.1) 76 (28.3) 76 (28.3) 90 (33.4) 72 (26.8)  
PAM50
 Luminal A 229 (21.3) 25 (9.3) 51 (19.0) 71 (26.4) 82 (30.5) < 0.01
 Luminal B 122 (11.3) 22 (8.2) 25 (9.3) 28 (10.4) 47 (17.5)
 HER2-enriched & Basal-like 155 (14.4) 84 (31.2) 41 (15.2) 22 (8.2) 8 (3.0)
 Unknown 570 (53.0) 138 (51.3) 152 (56.5) 148 (55.0) 132 (49.0)  
Clinical stage
 I/II 568 (52.8) 136 (50.6) 149 (55.4) 136 (50.6) 147 (54.6) 0.26
 III/IV 187 (17.4) 56 (20.8) 38 (14.1) 44 (16.3) 49 (18.2)
 Unknown 321 (29.8) 77 (28.6) 82 (30.5) 89 (33.1) 73 (27.1)  
  1. a Pearson chi-squared test. Unknown data was not accounted in the test
  2. bPatients were divided into quartiles according to DNAm age. First quartile: 2.2–37.6; Second quartile: 37.7–49.8; Third quartile: 49.9–64.9; Fourth quartile: 65–157
  3. Significant ones are in boldface