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Table 2 Univariate and multivariate Cox proportional hazards regression for disease-free survival

From: A molecular and staging model predicts survival in patients with resected non-small cell lung cancer

Variables Category Univariate Multivariate
HR 95%CI P-value HR 95%CI P-value
Age (years) < 60 1.00      
≥60 1.81 0.95–3.67 0.089    
Gender Male 1.00      
Female 1.04 0.83–1.50 0.884    
Smoking status Never-smoker 1.00      
Ever-smoker 1.05 0.79–1.86 0.913    
TNM stage I 1.00    1.00   
II 1.35 1.16–2.48 0.002 1.33 1.11–2.45 0.003
III 2.24 1.39–3.59 <0.001 2.32 1.45–3.68 <0.001
Grade Well-differentiated 1.00    1.00   
Moderately-differentiated 1.24 1.10–2.28 0.008 1.27 1.12–2.40 0.005
Poorly-differentiated 1.81 1.53–2.92 <0.001 1.85 1.55–2.93 <0.001
Histology Squamous cell carcinoma 1.00      
Adenocarcinoma 0.97 0.73–1.48 0.241    
Adjuvant therapy Yes 1.00    1.00   
No 0.90 0.80–0.96 0.042 0.93 0.82–1.04 0.059
TPX2 Negative 1.00    1.00   
Positive 1.62 1.21–2.35 <0.001 1.60 1.18–2.31 <0.001
MMP12 Negative 1.00    1.00   
Positive 1.76 1.32–2.61 <0.001 1.74 1.30–2.59 <0.001