Table 2 Univariate and multivariate Cox proportional hazards regression for disease-free survival
From: A molecular and staging model predicts survival in patients with resected non-small cell lung cancer
Variables | Category | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
HR | 95%CI | P-value | HR | 95%CI | P-value | ||
Age (years) | < 60 | 1.00 | |||||
≥60 | 1.81 | 0.95–3.67 | 0.089 | ||||
Gender | Male | 1.00 | |||||
Female | 1.04 | 0.83–1.50 | 0.884 | ||||
Smoking status | Never-smoker | 1.00 | |||||
Ever-smoker | 1.05 | 0.79–1.86 | 0.913 | ||||
TNM stage | I | 1.00 | 1.00 | ||||
II | 1.35 | 1.16–2.48 | 0.002 | 1.33 | 1.11–2.45 | 0.003 | |
III | 2.24 | 1.39–3.59 | <0.001 | 2.32 | 1.45–3.68 | <0.001 | |
Grade | Well-differentiated | 1.00 | 1.00 | ||||
Moderately-differentiated | 1.24 | 1.10–2.28 | 0.008 | 1.27 | 1.12–2.40 | 0.005 | |
Poorly-differentiated | 1.81 | 1.53–2.92 | <0.001 | 1.85 | 1.55–2.93 | <0.001 | |
Histology | Squamous cell carcinoma | 1.00 | |||||
Adenocarcinoma | 0.97 | 0.73–1.48 | 0.241 | ||||
Adjuvant therapy | Yes | 1.00 | 1.00 | ||||
No | 0.90 | 0.80–0.96 | 0.042 | 0.93 | 0.82–1.04 | 0.059 | |
TPX2 | Negative | 1.00 | 1.00 | ||||
Positive | 1.62 | 1.21–2.35 | <0.001 | 1.60 | 1.18–2.31 | <0.001 | |
MMP12 | Negative | 1.00 | 1.00 | ||||
Positive | 1.76 | 1.32–2.61 | <0.001 | 1.74 | 1.30–2.59 | <0.001 | |